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Expression of chemerin correlates with a poor prognosis in female breast cancer patients

Authors El-Sagheer G, Gayyed M, Ahmad A, Abd El-Fatah A, Mohamed M

Received 26 June 2018

Accepted for publication 4 September 2018

Published 23 October 2018 Volume 2018:10 Pages 169—176

DOI https://doi.org/10.2147/BCTT.S178181

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Pranela Rameshwar


Ghada El-Sagheer,1 Mariana Gayyed,2 Asmaa Ahmad,1 Aliaa Abd El-Fattah,3 Manar Mohamed4

1Endocrinology Unit, Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 2Department of Pathology, Minia Faculty of Medicine, Minia University, Minia, Egypt; 3Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 4Department of Internal Medicine, Deraya University, Minia, Egypt

Objective: Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis.
Methods: We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients’ clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis.
Results: We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (P=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (P=0.01). Chemerin expression was significantly correlated with weight (r=0.256, P=0.04), body mass index (r=0.233, P=0.03), tumor size (r=0.235, P=0.03), lymph node metastasis (r=0.265, P=0.045), distant metastasis (r=0.267, P=0.02), and tumor grading, (r=0.421, P=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (P=0.038, r=-0.437, and P=0.047, r=–0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (P<0.001, sensitivity 89%, and specificity 69%). The Kaplan–Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (P=0.001).
Conclusion: Our results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients.

Keywords:
chemerin expression, breast cancer, adipocyte development, obesity

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