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Expression and significance of RRBP1 in esophageal carcinoma

Authors Wang L, Wang M, Zhang M, Li X, Zhu Z, Wang H

Received 24 November 2017

Accepted for publication 18 January 2018

Published 17 May 2018 Volume 2018:10 Pages 1243—1249

DOI https://doi.org/10.2147/CMAR.S158013

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Liang Wang,1 Ming Wang,2 Mingyun Zhang,1 Xingde Li,1 Zhongcheng Zhu,1 Haiyan Wang2

1Department of Endoscopic Professional, Cangzhou Central Hospital, Cangzhou, China; 2Department of Radiation Therapy, Cangzhou Central Hospital, Cangzhou, China

Objective: This study was to investigate the expression and clinical significance of RRBP1 in esophageal carcinoma.
Materials and methods: RRBP1 expression was detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the relationship of RRBP1 with clinicopathological characteristics and prognosis was analyzed.
Results: RRBP1 was highly expressed in esophageal carcinoma tissues compared with matched adjacent normal tissues (P<0.05). Moreover, RRBP1 expression was associated with T stage, lymph node metastasis, and TNM stage in esophageal carcinoma (P<0.05). Survival analysis revealed that RRBP1, T stage, lymph node metastasis, and TNM stage were significantly associated with patients’ prognosis.
Conclusion: RRBP1 is highly expressed in esophageal carcinoma and can serve as a potential biomarker to predict patients’ prognosis.

Keywords: RRBP1, prognosis, esophageal carcinoma, survival analysis

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