Expression and significance of RRBP1 in esophageal carcinoma
Authors Wang L, Wang M, Zhang M, Li X, Zhu Z, Wang H
Received 24 November 2017
Accepted for publication 18 January 2018
Published 17 May 2018 Volume 2018:10 Pages 1243—1249
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Harikrishna Nakshatri
Liang Wang,1 Ming Wang,2 Mingyun Zhang,1 Xingde Li,1 Zhongcheng Zhu,1 Haiyan Wang2
1Department of Endoscopic Professional, Cangzhou Central Hospital, Cangzhou, China; 2Department of Radiation Therapy, Cangzhou Central Hospital, Cangzhou, China
Objective: This study was to investigate the expression and clinical significance of RRBP1 in esophageal carcinoma.
Materials and methods: RRBP1 expression was detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the relationship of RRBP1 with clinicopathological characteristics and prognosis was analyzed.
Results: RRBP1 was highly expressed in esophageal carcinoma tissues compared with matched adjacent normal tissues (P<0.05). Moreover, RRBP1 expression was associated with T stage, lymph node metastasis, and TNM stage in esophageal carcinoma (P<0.05). Survival analysis revealed that RRBP1, T stage, lymph node metastasis, and TNM stage were significantly associated with patients’ prognosis.
Conclusion: RRBP1 is highly expressed in esophageal carcinoma and can serve as a potential biomarker to predict patients’ prognosis.
Keywords: RRBP1, prognosis, esophageal carcinoma, survival analysis
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