Back to Journals » Therapeutics and Clinical Risk Management » Volume 15

Explorative analysis of gender-specific characteristics in patients with heart failure in an Italian hospital

Authors Perrone V, Veronesi C, Nica M, Colombo D, Degli Esposti L, Castello R

Received 26 January 2019

Accepted for publication 6 June 2019

Published 8 July 2019 Volume 2019:15 Pages 847—850

DOI https://doi.org/10.2147/TCRM.S203011

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


V Perrone,1 C Veronesi,1 M Nica,2 D Colombo,2 L Degli Esposti,1 R Castello3

1Clicon S.R.L. Health, Economics and Outcomes Research, Ravenna, Italy; 2Novartis Pharma, Origgio, VA, Italy; 3Division of General Medicine, University Hospital of Verona, Verona, Italy

Abstract: Sex-related differences have been shown to deeply affect health-related aspects of patients. However, the lack of gender-specific analysis makes it difficult to advance personalized medicine in terms of a gender-based approach. The aim of the present study was to describe gender-specific features of patients diagnosed with heart failure (HF), with a focus on the clinical presentation. Data were collected from a properly designed database and referred to an Italian hospital. Patients aged ≥18 years with a primary or secondary diagnosis of HF between 1 January 2012 and 31 December 2016 were included, and their demographic and clinical characteristics were analyzed according to gender. Of the 719 HF patients included, 317 (44.1%) were male and 402 (55.9%) were female. Women tended to be older compared to men (82.4±8.8 years and 77.1±10.6 years, respectively). As for clinical presentation, 62.1% of female and 38.3% of male patients had preserved ejection fraction, and 56.1% of men and 58.2% of women suffered from atrial fibrillation. The left atrium was partially compromised in 62.4% of male and 63% of female patients, while right atrium dysfunction tended to be more frequent in male patients compared to female patients (29.1% and 25.5%, respectively). In conclusion, gender-specific features of a cohort of HF patients from a clinical setting were accurately described.

Keywords: gender, specific characteristics, heart failure, clinical setting

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]