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Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer

Authors Zhang P, Zhou H, Lu K, Lu Y, Wang Y, Feng T

Received 25 October 2017

Accepted for publication 28 November 2017

Published 9 January 2018 Volume 2018:11 Pages 291—299

DOI https://doi.org/10.2147/OTT.S155134

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


Ping Zhang, Hongxing Zhou, Kefeng Lu, Yunou Lu, Yan Wang, Tongbao Feng

Department of Clinical Laboratory, The Affiliated Changzhou No 2 People’s Hospital, Nanjing Medical University, Changzhou, People’s Republic of China

Background:
Breast cancer is the most common cancer in women worldwide. Cancer-secreted exosomes have recently been recognized as important mediators of intercellular communication. The aim of this study was to determine the role of exosomal long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in breast cancer progression.
Materials and methods: Breast cancer specimens were obtained with informed consent from patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect MALAT1 expression, and cellular proliferation was measured using cell counting kit-8 (CCK-8) assay.
Results: MALAT1 was highly expressed in breast cancer tissues and associated with disease progression. Breast cancer exosomes promoted cell proliferation and exosome-mediated MALAT1 to induce cell proliferation.
Conclusion: These findings indicated that exosomal MALAT1 could regulate cancer progression and represent a novel strategy for overcoming breast cancer.

Keywords: breast cancer, exosomes, MALAT1, cell proliferation

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