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Existing data sources for clinical epidemiology: Aarhus University Clinical Trial Candidate Database, Denmark

Authors Nørrelund H, Mazin W, Pedersen L

Received 4 January 2014

Accepted for publication 14 February 2014

Published 8 April 2014 Volume 2014:6 Pages 129—135

DOI https://doi.org/10.2147/CLEP.S60080

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Helene Nørrelund, Wiktor Mazin, Lars Pedersen

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

Abstract: Denmark is facing a reduction in clinical trial activity as the pharmaceutical industry has moved trials to low-cost emerging economies. Competitiveness in industry-sponsored clinical research depends on speed, quality, and cost. Because Denmark is widely recognized as a region that generates high quality data, an enhanced ability to attract future trials could be achieved if speed can be improved by taking advantage of the comprehensive national and regional registries. A "single point-of-entry" system has been established to support collaboration between hospitals and industry. When assisting industry in early-stage feasibility assessments, potential trial participants are identified by use of registries to shorten the clinical trial startup times. The Aarhus University Clinical Trial Candidate Database consists of encrypted data from the Danish National Registry of Patients allowing an immediate estimation of the number of patients with a specific discharge diagnosis in each hospital department or outpatient specialist clinic in the Central Denmark Region. The free access to health care, thorough monitoring of patients who are in contact with the health service, completeness of registration at the hospital level, and ability to link all databases are competitive advantages in an increasingly complex clinical trial environment.

Keywords: Denmark, single point-of-entry, patient registration

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