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Exceptional Symbiosis Between Tumors: A Case of Gastric Signet Ring Cell Metastasis in Chromophobe Carcinoma of the Kidney

Authors Cieri M, Carrara S, Colombo P

Received 17 December 2020

Accepted for publication 19 January 2021

Published 27 January 2021 Volume 2021:13 Pages 45—48

DOI https://doi.org/10.2147/RRU.S297465

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jan Colli


Miriam Cieri,1 Silvia Carrara,2 Piergiuseppe Colombo1

1Department of Pathology, Humanitas Clinical and Research Center – IRCCS, Rozzano, Milan, Italy; 2Department of Endoscopy, Humanitas Clinical and Research Center – IRCCS, Rozzano, Milan, Italy

Correspondence: Piergiuseppe Colombo
Department of Pathology, Humanitas Clinical and Research Center – IRCCS, Rozzano, via Manzoni 56, Rozzano, Milano CAP 20089, Italy
Email piergiuseppe.colombo@humanitas.it

Abstract: Tumor-to-tumor metastasis is the presence of a metastatic deposit within a second malignant primary, and its identification could be challenging, particularly when the latter malignancy has not yet been discovered. Renal cell carcinoma is one of the known recipients. Here we present a 52 years old woman who presented with a small nodule in the left kidney, which had a biphasic cell proliferation, chromophobe type, and signet-ring cell type for which we suggested to investigate the presence of a second tumor of gastrointestinal origin. We present this case for the rarity of its presentation, for the peculiar histological symbiosis we found between the two tumor entities, and for the challenging diagnosis due to the presence of an occult aggressive primary tumor.

Keywords: tumor-to-tumor metastasis, gastric signet-ring cell carcinoma, chromophobe carcinoma, kidney metastasis, renal cell carcinoma, cancer of unknown primary

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