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Examination of biomarker expressions in sepsis-related DIC patients

Authors Shimizu M, Konishi A, Nomura S

Received 10 May 2018

Accepted for publication 4 July 2018

Published 12 September 2018 Volume 2018:11 Pages 353—361

DOI https://doi.org/10.2147/IJGM.S173684

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Michiomi Shimizu, Akiko Konishi, Shosaku Nomura

First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan

Background: Disseminated intravascular coagulation (DIC) is the main cause of death among patients with sepsis. In particular, low platelet count is predictive of poor outcome. However, the significance of platelet activation in patients with sepsis-related DIC is poorly understood. To determine the characteristics of platelet-related abnormality in patients with sepsis-related DIC, we assessed the expression levels of several biomarkers.
Methods: Plasma levels of biomarkers, including cytokines, chemokines, soluble selectins, platelet-derived microparticles (PDMPs), soluble vascular adhesion molecule 1, and high mobility group box protein 1 were measured by enzyme-linked immunosorbent assay at baseline and after 4, 7, 14, and 21 days of DIC treatment.
Results: Differences in platelet activation and in the elevation of activated platelet-related PDMPs and of soluble P-selectin were seen between patients suffering from sepsis and hematologic malignancy with DIC. In addition, the elevation of interleukin (IL)-6 and thrombopoietin (TPO) was significant in sepsis patients with DIC. Furthermore, IL-6 and TPO promoted platelet activation in vitro.
Conclusion: Assessment of PDMPs, sP-selectin, IL-6, and TPO may be beneficial in the primary prevention of multi-organ failure in sepsis patients with DIC.

Keywords: disseminated intravascular coagulation, platelet activation, PDMP, sP-selectin, IL-6, TPO

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