Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 8

Exacerbation-related impairment of quality of life and work productivity in severe and very severe chronic obstructive pulmonary disease

Authors Solem CT, Sun SX, Sudharshan L, Macahilig C, Katyal M, Gao X

Received 9 July 2013

Accepted for publication 7 September 2013

Published 10 December 2013 Volume 2013:8 Pages 641—652

DOI https://doi.org/10.2147/COPD.S51245

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Caitlyn T Solem,1 Shawn X Sun,2 Lavanya Sudharshan,1 Cynthia Macahilig,3 Monica Katyal,3 Xin Gao1

1Pharmerit International, Bethesda, MD, USA; 2Forest Research Institute, Jersey City, NJ, USA; 3Medical Data Analytics, Parsippany, NJ, USA

Purpose: Exacerbation-associated health-related quality of life (HRQoL) in patients with severe and very severe chronic obstructive pulmonary disease (COPD) is ill-defined. This study describes patterns, HRQoL, and the work productivity impact of COPD-related moderate and SEV exacerbations in patients with SEV/VSEV COPD, focusing on the chronic bronchitis subtype.
Patients and methods: A US sample of SEV and VSEV COPD patients with recent moderate or SEV exacerbation was recruited. Along with the demographic and clinical data collected from medical records, patients reported on exacerbation frequency, health-related quality of life (HRQoL) (using the St George’s Respiratory Questionnaire for COPD [SGRQ-C] and the European Quality of Life-5 Dimensions [EQ-5D]™ index), and work productivity and activity impairment (using the Work Productivity and Activity Impairment Questionnaire - Specific Health Problem [WPAI-SHP]). The HRQoL-related impacts of exacerbation frequency, time since exacerbation, and last exacerbation severity were evaluated via linear regressions.
Results: A total of 314 patients (190 SEV/124 VSEV, mean age =68.0 years, 51% male, 28% current smokers) were included. In the previous 12 months, patients reported an average of 1.8 moderate exacerbations and 0.9 SEV exacerbations. Overall, 16% of patients were employed and reported a high percentage of overall work impairment (42.4% ± 31.1%). Activity impairment was positively associated with recent exacerbation severity (SEV 64.6% ± 26.8% versus moderate 55.6% ± 28.2%) (P=0.006). The HRQoL was significantly worse for SEV versus VSEV COPD (EQ-5D: 0.62 ± 0.23 versus 0.70 ± 0.17, respectively, and SGRQ-C: 70.1 ± 21.3 versus 61.1 ± 19.0, respectively) (P<0.001). Worse current HRQoL was reported by patients with a SEV versus moderate recent exacerbation (EQ-5D: 0.63 ± 0.21 versus 0.70 ± 0.20, respectively) (P=0.003); SGRQ-C: 70.3 ± 19.9 versus 61.7 ± 20.1, respectively (P<0.001). One additional exacerbation in the previous 12 months was associated with a 2.4-point SGRQ-C increase and a 0.02-point EQ-5D index decrease.
Conclusion: The severity and frequency of COPD-related moderate/SEV exacerbations in SEV and VSEV COPD patients were positively associated with poor HRQoL and work productivity and activity impairment.

Keywords: burden, HRQoL, chronic obstructive pulmonary disease, health-related quality of life, exacerbations, utilities

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Treatment patterns, resource utilization, and outcomes among hospitalized patients with methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections in Lebanon and Saudi Arabia

Matar MJ, Moghnieh R, Alothman AF, Althaqafi AO, Alenazi TH, Farahat FM, Corman S, Solem CT, Raghubir N, Macahilig C, Haider S, Stephens JM

Infection and Drug Resistance 2017, 10:43-48

Published Date: 3 February 2017

Burden of methicillin-resistant Staphylococcus aureus pneumonia among hospitalized patients in Lebanon and Saudi Arabia

Althaqafi AO, Matar MJ, Moghnieh R, Alothman AF, Alenazi TH, Farahat F, Corman S, Solem CT, Raghubir N, Macahilig C, Haider S, Stephens JM

Infection and Drug Resistance 2017, 10:49-55

Published Date: 2 February 2017

Readers of this article also read:

COPD exacerbation frequency and its association with health care resource utilization and costs

Dhamane AD, Moretz C, Zhou Y, Burslem K, Saverno K, Jain G, Renda A, Kaila S

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2609-2618

Published Date: 3 December 2015

Treatment adherence in multiple sclerosis: a survey of Belgian neurologists

Decoo D, Vokaer M

Patient Preference and Adherence 2015, 9:1669-1676

Published Date: 19 November 2015

Cardiac autonomic modulation in healthy elderly after different intensities of dynamic exercise

Droguett VS, Santos AC, Medeiros CE, Marques DP, Nascimento LS, Brasileiro-Santos MS

Clinical Interventions in Aging 2015, 10:203-208

Published Date: 12 January 2015

Measuring quality of sleep and autonomic nervous function in healthy Japanese women

Sato M, Yasuhara Y, Tanioka T, Iwasa Y, Miyake M, Yasui T, Tomotake M, Kobayashi H, Locsin RC

Neuropsychiatric Disease and Treatment 2014, 10:89-96

Published Date: 17 January 2014