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Evidence-based treatments for cluster headache

Authors Gooriah R, Buture A, Ahmed F

Received 11 August 2015

Accepted for publication 24 September 2015

Published 9 November 2015 Volume 2015:11 Pages 1687—1696

DOI https://doi.org/10.2147/TCRM.S94193

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Rubesh Gooriah, Alina Buture, Fayyaz Ahmed

Department of Neurology, Hull Royal Infirmary, Kingston upon Hull, UK

Abstract: Cluster headache (CH), one of the most painful syndromes known to man, is managed with acute and preventive medications. The brief duration and severity of the attacks command the use of rapid-acting pain relievers. Inhalation of oxygen and subcutaneous sumatriptan are the two most effective acute therapeutic options for sufferers of CH. Several preventive medications are available, the most effective of which is verapamil. However, most of these agents are not backed by strong clinical evidence. In some patients, these options can be ineffective, especially in those who develop chronic CH. Surgical procedures for the chronic refractory form of the disorder should then be contemplated, the most promising of which is hypothalamic deep brain stimulation. We hereby review the pathogenesis of CH and the evidence behind the treatment options for this debilitating condition.

Keywords: cluster headache, pathogenesis, vasoactive intestinal peptide, suprachiasmatic nucleus

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