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Everolimus-eluting coronary stents

Authors Saez A, Moreno F

Published 13 September 2010 Volume 2010:3 Pages 51—56

DOI https://doi.org/10.2147/MDER.S4422

Review by Single-blind

Peer reviewer comments 2


Alejandro Saez, Raul Moreno
Division of Interventional Cardiology, University Hospital La Paz, Madrid, Spain

Abstract: Bare metal stents enabled a reduction in the risk of early procedural complications and restenosis in comparison with balloon angioplasty alone, but introduced a new and device-specific iatrogenic condition, ie, in-stent restenosis due to increased neointimal hyperplasia. Sirolimus- and paclitaxel-eluting stents reduce restenosis and the need for new revascularizations in comparison with bare metal stents, although at the cost of a slight increase in the risk of late stent thrombosis and a need for prolonged dual antiplatelet therapy. Everolimus is an analog of sirolimus with an increased solubility. In this review, the currently available evidence for everolimus-eluting stents is revised, including randomized trials against bare metal stents, and head-to-head trials comparing this stent with other drug-eluting stents.

Keywords: coronary stents, restenosis, everolimus, review

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