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Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Authors Moradi M, Foroutanfar A

Received 27 May 2017

Accepted for publication 14 July 2017

Published 4 October 2017 Volume 2017:13 Pages 361—367

DOI https://doi.org/10.2147/VHRM.S142721

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Takashi Kajiya


Maryam Moradi, Ali Foroutanfar

Radiology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran

Background: Vitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD.
Materials and methods: Using a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques).
Results: The mean age of the participants was 60.5±10.6 years and the mean serum vitamin D level was 26.2±15.9 ng/dL (range, 3.5–83.2 ng/dL). Overall, 6.1% of the participants (n=11) had vitamin D deficiency, 56.1% (n=101) had insufficient levels of vitamin D, and 37.8% (n=68) had sufficient levels of vitamin D. The mean serum vitamin D level was significantly lower in patients with severe CAD (P=0.004). The serum vitamin D level in the “positive for CAD” group was 20.98 ng/mL, significantly lower than the level in the “negative for CAD” group (30.47 ng/mL; P<0.001). The mean calcium score among participants was 533.5±87.9. Based on the Spearman test, a significant negative correlation (–0.21) was detected between the serum vitamin D level and coronary artery calcium score (CACS) (P=0.005). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and sufficient vitamin D groups (P<0.001 for both comparisons).
Conclusion: Vitamin D deficiency was associated with coronary artery calcification and severity of coronary artery stenosis in Iranian patients.

Keywords: coronary artery disease, vitamin D, multidetector computed tomography, atherosclerosis, angiography

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