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Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients

Authors Sorour NE, Elesawy FM, Tabl HA, Ibrahim ME, Akl EM

Received 15 October 2018

Accepted for publication 7 January 2019

Published 8 February 2019 Volume 2019:12 Pages 109—114

DOI https://doi.org/10.2147/CCID.S190917

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Neveen E Sorour,1 Fatma M Elesawy,1 Hala A Tabl,2 Mohammed E Ibrahim,3 Essam M Akl1

1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt; 2Department of Microbiology and Immunology, Faculty of Medicine, Benha University, Benha, Egypt; 3Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, Egypt

Background: Pruritus is a common symptom in end-stage renal failure. Many patients suffer from this severe distressing symptom. Although several factors have been postulated to explain uremic pruritus, there is not any conclusive evidence for one of these factors.
Objectives: We aimed to evaluate serum levels of brain-derived nerve growth factor (BDNF), neurotrophin-4 (NT-4), serum calcium, phosphors and parathyroid hormone in uremic patients with pruritus and without pruritus compared to control subjects.
Methods: One hundred twenty patients suffering from renal failure and 60 healthy subjects were included in the study. Serum BDNF and NT4 levels were determined by ELISA. The serum calcium, phosphorus, parathyroid hormone and hemoglobin were also evaluated.
Results: Serum BDNF was significantly higher in uremic patients with pruritus (P=0.0026) and uremic patients without pruritus (P=0.0294) than control subjects. In addition, NT-4 levels were significantly elevated in uremic patients with pruritus (P<0.0001) and uremic patients without pruritus than control subjects (P=0.0016). There was no significant difference of serum level of BDNF between uremic patients with pruritus and uremic patients without pruritus (P=0.1215). However, serum NT-4 was higher in uremic patients with pruritus vs nonpruritic uremic patients with a significant difference (P=0.0026). There was a positive significant correlation between serum level of NT-4 and severity of pruritus (P=0.024).
Conclusion: The present study shows that NT-4 level is increased in the serum of uremic patients with pruritus and there was a significant correlation between NT-4 and severity of pruritus suggesting that NT-4 may have a role in uremic pruritus.

Keywords: brain-derived neurotrophic factor, neurotrophin-4, uremic pruritus


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