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Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study

Authors Wolide AD, Zawdie B, Alemayehu T, Tadesse S

Received 21 August 2016

Accepted for publication 27 October 2016

Published 2 December 2016 Volume 2016:9 Pages 417—424

DOI https://doi.org/10.2147/DMSO.S120326

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Amare Desalegn Wolide,1 Belay Zawdie,2 Tilahun Alemayehu,3 Samuel Tadesse1

1Department of Medical Physiology, 2Department of Medical Biochemistry, 3Department of Human Anatomy, College of Health Sciences, Jimma University, Jimma, Ethiopia

Background: The chronic hyperglycemia of diabetes has been associated with an imbalance of some trace metal elements in the blood sample of type 2 diabetes patients.
Aim: To evaluate the status of serum ferritin and some selected metal elements among type 2 diabetes mellitus (T2DM) patients.
Methods: Facility-based comparative cross-sectional study was conducted from February 15, 2015 to October 30, 2015, at Jimma University Specialized Hospital, Ethiopia. A total of 428 type 2 diabetes and nondiabetes study subjects were recruited to the study. After overnight fasting, 10 mL of venous blood samples were taken for biochemical and trace metal element analysis. Data were entered into EpiData version 3.5.1 and exported to SPSS version 20 for Windows for analysis.
Results: Serum concentration of Zn+2, Mg+2, Cr+3, ferritin, and Fe+3 in patients with type 2 diabetes was significantly lower (p<0.0001) than nondiabetes patients. In contrast, serum Cu+2 was significantly higher (p<0.0001) in type 2 diabetes patients than nondiabetics. In addition, significant differences were not seen in both groups with regard to serum Mn+2, Ca+2, and Po4−3. Waist-to-hip ratio (WHR), serum Fe+3, ferritin, and Mn+2 were significantly higher among oral hypoglycemic agent users of type 2 diabetes patients than the injectable insulin users. Serum Zn+2 had significant positive correlation with serum Mg+2 (r=0.738), Cr+3 (r=0.233), Ca+2 (r=0.238), and Po4−3 (r=0.222). In addition, serum Zn+2 had shown significant and negative correlation with body mass index (BMI, r=−0.331), WHR (r=−0.340), and fasting blood glucose (FBG, r=−0.186). Likewise, serum Mg+2 and Po4−3 are significantly and negatively correlated with BMI, WHR, and FBG.
Conclusion: The imbalance of trace metal elements in the blood sample of diabetes is uncertain. Thus, we recommend a prospective cohort study to find out the principal factors behind the problem.

Keywords: diabetes, ferritin, trace metal elements, hyperglycemia, insulin, metal

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