Evaluation of Peripheral Blood Parameters of Pulmonary Tuberculosis Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: Comparative Study
Authors Kahase D, Solomon A, Alemayehu M
Received 4 November 2019
Accepted for publication 9 March 2020
Published 1 April 2020 Volume 2020:11 Pages 115—121
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Martin H Bluth
Daniel Kahase, Absra Solomon, Mihret Alemayehu
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wolkite University, Gubrie, Wolkite, Ethiopia
Correspondence: Daniel Kahase
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wolkite University, P.O. Box: 07, Gubrie, Wolkite, Ethiopia
Tel +251 9 1241 4564
Fax +251 11 322 0041
Background and Aim: Pulmonary tuberculosis is still among the leading cause of morbidity and mortality in Ethiopia. Different hematological abnormalities are commonly associated with pulmonary tuberculosis even though inconsistent results have been described. Hence, this study aimed to evaluate the hematological parameters of pulmonary tuberculosis patients visited St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia.
Methods: From April to September 2018, a comparative cross-sectional study was conducted among pulmonary tuberculosis patients (n=40) and control patients (n=40). About 5 mL venous blood and 2– 5 mL sputum samples were collected and examined by Cell Dyn 1800 hematology analyzer and cultured using Mycobacteria Growth Indicator Tube (BACTEC MGIT 960), respectively. Independent t-test was performed with the help of SPSS version 20 software, and p-value < 0.05 was considered as statistically significant difference.
Results: The proportion of male to female in the pulmonary tuberculosis patients (PTB) and the control patients was 1.7 (25/15). Two-sample independent t-test revealed that the mean values of hemoglobin level (P=0.002), hematocrit (P=0.018), mean cell hemoglobin concentration (P=0.001) and relative lymphocyte percentage (P=0.036) of PTB were significantly lower than the control group. Moreover, significantly higher mean values were also observed in total white blood cell count (P=0.004), platelet count (P< 0.001) and erythrocyte sedimentation rate (P< 0.001). Among the hematologic abnormalities detected, thrombocytosis and anemia presented in 65% and 25% of PTB patients, respectively.
Conclusion: Statistically significant mean differences were observed in hemoglobin, hematocrit (HCT), MCHC, relative lymphocyte percentage, WBC, platelet count, relative neutrophil percentage and ESR values. So, the utilization of such data is important in providing preliminary information for diagnosis and management of pulmonary tuberculosis. In fact, a further large scale study is needed to substantiate this finding.
Keywords: hematologic parameter, Mycobacterium tuberculosis, thrombocytosis, anemia
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