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Evaluation of Peripheral Blood Parameters of Pulmonary Tuberculosis Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: Comparative Study

Authors Kahase D, Solomon A, Alemayehu M

Received 4 November 2019

Accepted for publication 9 March 2020

Published 1 April 2020 Volume 2020:11 Pages 115—121

DOI https://doi.org/10.2147/JBM.S237317

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Martin H Bluth


Daniel Kahase, Absra Solomon, Mihret Alemayehu

Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wolkite University, Gubrie, Wolkite, Ethiopia

Correspondence: Daniel Kahase
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wolkite University, P.O. Box: 07, Gubrie, Wolkite, Ethiopia
Tel +251 9 1241 4564
Fax +251 11 322 0041
Email danielasalfew@gmail.com

Background and Aim: Pulmonary tuberculosis is still among the leading cause of morbidity and mortality in Ethiopia. Different hematological abnormalities are commonly associated with pulmonary tuberculosis even though inconsistent results have been described. Hence, this study aimed to evaluate the hematological parameters of pulmonary tuberculosis patients visited St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia.
Methods: From April to September 2018, a comparative cross-sectional study was conducted among pulmonary tuberculosis patients (n=40) and control patients (n=40). About 5 mL venous blood and 2– 5 mL sputum samples were collected and examined by Cell Dyn 1800 hematology analyzer and cultured using Mycobacteria Growth Indicator Tube (BACTEC MGIT 960), respectively. Independent t-test was performed with the help of SPSS version 20 software, and p-value < 0.05 was considered as statistically significant difference.
Results: The proportion of male to female in the pulmonary tuberculosis patients (PTB) and the control patients was 1.7 (25/15). Two-sample independent t-test revealed that the mean values of hemoglobin level (P=0.002), hematocrit (P=0.018), mean cell hemoglobin concentration (P=0.001) and relative lymphocyte percentage (P=0.036) of PTB were significantly lower than the control group. Moreover, significantly higher mean values were also observed in total white blood cell count (P=0.004), platelet count (P< 0.001) and erythrocyte sedimentation rate (P< 0.001). Among the hematologic abnormalities detected, thrombocytosis and anemia presented in 65% and 25% of PTB patients, respectively.
Conclusion: Statistically significant mean differences were observed in hemoglobin, hematocrit (HCT), MCHC, relative lymphocyte percentage, WBC, platelet count, relative neutrophil percentage and ESR values. So, the utilization of such data is important in providing preliminary information for diagnosis and management of pulmonary tuberculosis. In fact, a further large scale study is needed to substantiate this finding.

Keywords: hematologic parameter, Mycobacterium tuberculosis, thrombocytosis, anemia

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