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Evaluation of patients with diffuse unilateral subacute neuroretinitis by spectral domain optical coherence tomography with enhanced depth imaging

Authors Berbel R, Casella AM, de Souza E, Farah ME

Received 8 January 2014

Accepted for publication 22 February 2014

Published 5 June 2014 Volume 2014:8 Pages 1081—1087

DOI https://doi.org/10.2147/OPTH.S60302

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Rodrigo F Berbel,1 Antonio Marcelo B Casella,1 Eduardo C de Souza,2 Michel E Farah2

1State University of Londrina, Londrina, 2Federal University of São Paulo, São Paulo, Federative Republic of Brazil

Background: The purpose of this study was to determine the value of spectral domain ­optical coherence tomography (SD-OCT) in assessing patients with diffuse unilateral subacute neuroretinitis (DUSN).
Methods: This was an observational case series with clinical imaging correlation performed at the Retina and Vitreous Institute of Londrina and State University of Londrina, Paraná, Brazil. The series comprised ten consecutive patients with a confirmed diagnosis of DUSN, ie, seven patients with late-stage disease and three with early-stage disease, who were assessed by SD-OCT for mean macular, retinal nerve fiber layer, and choroidal thickness using enhanced depth imaging software.
Results: Comparing the affected eye with the healthy fellow eye, significant diffuse atrophy of the retinal layers with a decrease in mean macular (P=0.004) and retinal nerve fiber layer (P=0.002) thickness was found in all cases. There was no difference in choroidal thickness (P=0.262).
Conclusion: The correlation of SD-OCT results with central vision and funduscopic findings may explain the profound loss of visual function in patients with DUSN.

Keywords: eye infections, parasitic, retinitis, optical coherence tomography, diffuse unilateral subacute neuroretinitis, enhanced depth imaging

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