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Evaluation of oxidative response and tissular damage in rat lungs exposed to silica-coated gold nanoparticles under static magnetic fields

Authors Ferchichi S, Trabelsi H, Azzouz I, Hanini A, Rejeb A, Tebourbi O, Sakly M, Abdelmelek H

Received 25 December 2015

Accepted for publication 24 February 2016

Published 8 June 2016 Volume 2016:11 Pages 2711—2719

DOI https://doi.org/10.2147/IJN.S103140

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Dr Thomas J Webster


Soumaya Ferchichi,1 Hamdi Trabelsi,1 Inès Azzouz,1 Amel Hanini,2 Ahmed Rejeb,3 Olfa Tebourbi,1 Mohsen Sakly,1 Hafedh Abdelmelek1

1Laboratory of Integrative Physiology, Faculty Of Sciences of Bizerte, 2Laboratory of Vascular Pathology, Carthage University, Carthage 3Laboratory of Pathological Anatomy, National School of Veterinary Medicine of Sidi Thabet, Manouba Univeristy, Manouba, Tunisia

Abstract: The purpose of our study was the evaluation of toxicological effects of silica-coated gold nanoparticles (GNPs) and static magnetic fields (SMFs; 128 mT) exposure in rat lungs. Animals received a single injection of GNPs (1,100 µg/kg, 100 nm, intraperitoneally) and were exposed to SMFs, over 14 days (1 h/day). Results showed that GNPs treatment induced a hyperplasia of bronchus-associated lymphoid tissue. Fluorescence microscopy images showed that red fluorescence signal was detected in rat lungs after 2 weeks from the single injection of GNPs. Oxidative response study showed that GNPs exposure increased malondialdehyde level and decreased CuZn-superoxide dismutase, catalase, and glutathione peroxidase activities in rat lungs. Furthermore, the histopathological study showed that combined effects of GNPs and SMFs led to more tissular damages in rat lungs in comparison with GNPs-treated rats. Interestingly, intensity of red fluorescence signal was enhanced after exposure to SMFs indicating a higher accumulation of GNPs in rat lungs under magnetic environment. Moreover, rats coexposed to GNPs and SMFs showed an increased malondialdehyde level, a fall of CuZn-superoxide dismutase, catalase, and glutathione peroxidase activities in comparison with GNPs-treated group. Hence, SMFs exposure increased the accumulation of GNPs in rat lungs and led to more toxic effects of these nanocomplexes.

Keywords: malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, bronchus-associated lymphoid tissue, nanotoxicity, histopathological study

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