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Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics

Authors Shi G, Han X, Wang Q, Ding Y, Liu H, Zhang Y, Dai Y

Received 21 May 2020

Accepted for publication 26 June 2020

Published 20 July 2020 Volume 2020:12 Pages 6019—6031

DOI https://doi.org/10.2147/CMAR.S262973

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Gaofeng Shi,1,* Xue Han,1,* Qi Wang,1 Yan Ding,1 Hui Liu,1 Yunfei Zhang,2 Yongming Dai2

1Department of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People’s Republic of China; 2Department of Research Collaboration Hospital (MRI), Central Research Institute, United Imaging Healthcare, Shanghai 201800, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Hui Liu; Yunfei Zhang Tel +86-311-86095716
; Tel +86-311-86095716
Fax +86-311-8609-5692
Email liuhui_lh111@163.com yunfei.zhang@united-imaging.com

Purpose: To predict multiple prognostic factors of HCC including histopathologic grade, the expression of Ki67 as well as capsule formation with intravoxel incoherent motions imaging by extracting the histogram metrics.
Patients and Methods: A total of 52 patients with HCC were recruited with the MR examinations undertaken at a 3T scanner. Histogram metrics were extracted from IVIM-derived parametric maps. Independent student t-test was performed to explore the differences in metrics across different subtypes of prognostic factors. Spearman correlation test was utilized to evaluate the correlations between the IVIM metrics and prognostic factors. ROC analysis was applied to evaluate the diagnostic performance.
Results: According to the independent student t-test, there were 18, 4, and 8 IVIM-derived histogram metrics showing the capability for differentiating the subtypes of histopathologic grade, Ki67, and capsule formation, respectively, with P-values of less than 0.05. Besides, there existed a lot of significant correlations between IVIM metrics and prognostic factors. Finally, by integrating different histogram metrics showing significant differences between various subgroups together via establishing logistic regression based diagnostic models, greatest diagnostic power was obtained for grading HCC (AUC=0.917), diagnosing patients with highly expressed Ki67 (AUC=0.861) and diagnosing patients with capsule formation (AUC=0.839).
Conclusion: Multiple prognostic factors including histopathologic grade, Ki67 expression status, and capsule formation can be accurately predicted with assistance of histogram metrics sourced from a single IVIM scan.

Keywords: diffusion magnetic resonance imaging, intravoxel incoherent motions, hepatocellular carcinoma, prognostic factors, histogram analysis

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