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Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Authors Wang M, Lai X, Shao L, Li L

Received 11 April 2018

Accepted for publication 5 June 2018

Published 1 August 2018 Volume 2018:13 Pages 4445—4459

DOI https://doi.org/10.2147/IJN.S170745

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Mohankandhasamy Ramasamy

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Menglei Wang,1 Xuan Lai,2 Longquan Shao,2 Li Li1

1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China; 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China

Abstract: Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating that skin exposure is a means for NPs to enter the body. The distribution and interaction of NPs with skin cells may cause toxic side effects. In this review, possible penetration pathways and related toxicity mechanisms are discussed. The limitations of current experimental methods on the penetration and toxic effects of metallic NPs are also described. This review contributes to a better understanding of the risks of topically applied metallic NPs and provides a foundation for future studies.

Keywords: metallic nanoparticles, transdermal penetration, toxicity

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