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Evaluation of hypoglycemic, antihyperglycemic and antihyperlipidemic activities of 80% methanolic seed extract of Calpurnia aurea (Ait.) Benth. (Fabaceae) in mice

Authors Belayneh YM, Birru EM, Ambikar D

Received 14 April 2019

Accepted for publication 2 July 2019

Published 25 July 2019 Volume 2019:11 Pages 73—83

DOI https://doi.org/10.2147/JEP.S212206

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Bal Lokeshwar


Yaschilal Muche Belayneh,1 Eshetie Melese Birru,2 Digambar Ambikar2

1Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

Background: Diabetes mellitus is one of the most common chronic health problems in the world. As currently available antidiabetic medications have limitations in terms of safety, efficacy, and cost, it is an important research area to investigate medicinal plants for new antidiabetic compounds that can lead to effective, safe and less costly pharmacotherapy. The present study was done to evaluate the antidiabetic and antidyslipidemic activities of 80% methanolic seed extract of Calpurnia aurea (Ait.) Benth. (Fabaceae) in mice.
Methods: Blood glucose lowering activity of three doses (2.75 mg/kg, 5.5 mg/kg and 11 mg/kg) of the hydromethanolic seed extract of Calpurnia aurea was studied in three animal models: normoglycemic mice, oral glucose-loaded mice, and streptozotocin-induced diabetic mice. Additionally, the effect of the seed extract on body weight and serum lipid profile was studied in the streptozotocin-induced diabetic mice. Glibenclamide (5 mg/kg) was used as a standard drug in all animal models of the study. Blood glucose level was measured using a glucose meter, whereas serum lipid level was measured using an automated chemistry analyzer. Data were analyzed using one-way analysis of variance followed by Tukey’s post hoc multiple comparison test.
Results: Hydromethanolic extract of C. aurea seeds showed blood glucose lowering activity in all animal models, and it improved body weight loss and diabetic dyslipidemia in diabetic mice after 14 days of treatment.
Conclusion: This study revealed that hydromethanolic extract of Calpurnia aurea seeds has significant hypoglycemic, antihyperglycemic and antihyperlipidemic activities.

Keywords: diabetes mellitus, calpurnia aurea, streptozotocin, seed, mice

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