Back to Browse Journals » International Journal of General Medicine » Volume 6

Evaluation of coagulation parameters and liver enzymes among alcohol drinkers in Port Harcourt, Nigeria

Authors Adias TC, Egerton E, Erhabor O

Received 30 January 2013

Accepted for publication 4 April 2013

Published 14 June 2013 Volume 2013:6 Pages 489—494


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Teddy Charles Adias,1 Everton Egerton,2 Osaro Erhabor3

1Bayelsa College of Health Technology, Bayelsa State, Nigeria; 2Department of Medical Laboratory Science, Rivers State University of Science and Technology, Port Harcourt, Nigeria; 3Faculty of Medical Laboratory Science, Department of Haematology and Transfusion Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

Abstract: Alcohol is a major contributor to the global burden of disease, disability, and death in high, middle, and low-income countries. Harmful use of alcohol is one of the main factors contributing to premature deaths and avoidable disease burden worldwide and has a major impact on public health. The aim of this present cross-sectional study was to investigate the effect of alcohol consumption on coagulation parameters and liver enzymes of subjects in Port Harcourt, Nigeria. Two hundred adults consisting of 120 alcohol dependent subjects and 80 age, gender-matched nondrinkers aged 25–65 years (mean age 45.25 ± 11.50 years) were enrolled in this study. Of the 120 chronic alcohol drinkers, 37 were dependent on local dry gin, while 83 were dependent on other alcoholic beverages. The mean values of the liver enzymes, aspartate aminotransferase and gamma glutamyl transferase, were significantly higher (P = 0.002 and P = 0.02 respectively) among the chronic alcohol consumers compared with their nondrinker counterparts. Although the value of alanine aminotransferase was higher in the chronic drinkers, it did not reveal any significant difference (P = 0.11). The coagulation parameters, prothrombin time and activated partial thromboplastin time were investigated among chronic drinkers and nondrinkers. The mean value of prothrombin time and activated partial thromboplastin time was significantly higher in the chronic alcohol drinkers compared to the nondrinkers (P = 0.04 and P = 0.02 respectively). We observed a positive and significant correlation between values of liver enzymes, serum gamma glutamyl transferase and aspartate aminotransferase, and values of prothrombin time among alcohol consumers (r = 0.72 and r = 0.68 respectively). The implementation of policies to target harm reduction strategies among alcoholics is urgently needed, alongside the building of a strong base of public awareness and community support required for the continuity and sustainability of alcohol policies. There is also the need for the Nigerian government to enforce tighter regulations and restrictions on the production and distribution of alcoholic beverages to reduce harmful use, and protect young people and other vulnerable groups.

Keywords: coagulation parameters, liver enzymes, chronic alcoholics, Port Harcourt, Nigeria

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Antioxidant vitamin levels among preschool children with uncomplicated Plasmodium falciparum malaria in Sokoto, Nigeria

Aghedo FI, Shehu RA, Umar RA, Jiya MN, Erhabor O

Journal of Multidisciplinary Healthcare 2013, 6:259-263

Published Date: 11 July 2013

Glucose-6-phosphate dehydrogenase deficiency among children attending the Emergency Paediatric Unit of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria

Isaac IZ, Mainasara AS, Erhabor O, Omojuyigbe ST, Dallatu MK, Bilbis LS, Adias TC

International Journal of General Medicine 2013, 6:557-562

Published Date: 9 July 2013

Some hemostatic parameters in women with obstetric hemorrhage in Sokoto, Nigeria

Erhabor O, Isaac IZ, Muhammad AM, Abdulrahaman Y, Ezimah AC, Adias TC

International Journal of Women's Health 2013, 5:285-291

Published Date: 14 June 2013

Reproductive health options among HIV-infected persons in the low-income Niger Delta of Nigeria

Erhabor O, Akani CI, Eyindah CE

HIV/AIDS - Research and Palliative Care 2012, 4:29-35

Published Date: 9 February 2012

Effect of combined therapy of diabinese and nicotinic acid on liver enzymes in rabbits with dithizone-induced diabetes

Comfort C Monago, Frank Onwuka, Erhabor Osaro

Journal of Experimental Pharmacology 2010, 2:145-153

Published Date: 11 October 2010

Human immunodeficiency virus prevalence in an unbooked obstetric population in the Niger Delta

Chris I Akani, Erhabor Osaro, Dennis O Allagoa

HIV/AIDS - Research and Palliative Care 2010, 2:179-184

Published Date: 29 September 2010

Abnormal hemoglobin variants, ABO, and Rhesus blood group distribution among students in the Niger Delta of Nigeria

O Erhabor, TC Adias, Z A Jeremiah, et al

Pathology and Laboratory Medicine International 2010, 2:41-46

Published Date: 30 April 2010

Effect of amlodipine, a calcium channel antagonist, on gonadal steroid of male wistar albino rats

FC Onwuka, KC Patrick-I wuanyanwu, CK Nnodu, et al

Journal of Experimental Pharmacology 2010, 2:55-58

Published Date: 3 March 2010

The prevalence of human immunodeficiency virus infection among TB patients in Port Harcourt Nigeria

O Erhabor, Z A Jeremiah, T C Adias, et al

HIV/AIDS - Research and Palliative Care 2010, 2:1-5

Published Date: 14 January 2010

Thrombocytopenia in plasmodium parasitized pregnant women in the Niger Delta of Nigeria

O Erhabor, Z A Jeremiah, T C Adias, et al

Pathology and Laboratory Medicine International 2010, 2:1-5

Published Date: 6 January 2010

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects [Corrigendum]

Cui Y, Song Y, Wang J, Yu Z, Schuster A, Barrett YC, Frost C

Clinical Pharmacology: Advances and Applications 2014, 6:61-62

Published Date: 27 March 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Rao S, Song Y, Peddie F, Evans AM

International Journal of Nanomedicine 2011, 6:1245-1251

Published Date: 20 June 2011

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010