Back to Browse Journals » Clinical Optometry » Volume 3

Evaluation of carboxymethylcellulose 0.5%/glycerin 0.9% and sodium hyaluronate 0.18% artificial tears in patients with mild to moderate dry eye

Authors Roth HW, Conway T, Hollander DA

Published 25 November 2011 Volume 2011:3 Pages 73—78


Review by Single-blind

Peer reviewer comments 2

Hans-Walter Roth1, Taryn Conway2, David A Hollander2
1Institut für Wissenschaftliche Kontaktoptik Ulm, Ulm/Donau, Germany; 2Allergan, Inc, Irvine, CA, USA

Background: Artificial tears are commonly used for the symptomatic treatment of dry eye. This study compared the efficacy and safety of two preservative-free formulations of artificial tears, carboxymethylcellulose 0.5%/glycerin 0.9% (CMC/glycerin) and sodium hyaluronate 0.18% (sodium hyaluronate), in patients with mild to moderate dry eye symptoms.
Methods: This multicenter, investigator-masked, randomized, parallel-group, active-controlled, clinical study enrolled patients with mild to moderate dry eye symptoms. At baseline, patients received both treatments (one in each eye) and completed an Acute Preference Questionnaire. Patients were then randomized 1:1 to treatment with one drop of CMC/glycerin or sodium hyaluronate at least three times per day for 2 weeks. Efficacy outcomes included Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), corneal staining, conjunctival staining, conjunctival hyperemia, Dry Eye Symptom and Bothersomeness Survey, Patient Acceptability Questionnaire, and Patient Global Assessment of Change. Safety outcomes included the number and frequency of adverse events.
Results: CMC/glycerin and sodium hyaluronate produced statistically significant improvements in OSDI (P < 0.0001), TBUT (P < 0.0001), corneal staining (P < 0.0001), conjunctival staining (P < 0.0001 at Week 1; P < 0.01 at Week 2), and conjunctival hyperemia (P < 0.0001 at Week 1; P < 0.05 at Week 2) relative to baseline. No statistically significant between-group differences in any evaluated variable, including clinical and patient-reported outcomes, were observed. Following a single-drop instillation, there was a trend in favor of sodium hyaluronate for which each drop produced less blurring (P = 0.055). At Day 14, there were trends in favor of CMC/glycerin for questions about how many hours the eyedrops controlled symptoms (P = 0.057), whether the eyedrops effectively relieved dryness (P = 0.053), and which drop provided a cushion of moisture on eyes (P = 0.052). No treatment-related adverse events were reported.
Conclusion: Both CMC/glycerin and sodium hyaluronate effectively relieved dry eye symptoms. Scores were consistently similar across all measures, and both artificial tears were highly acceptable to patients.

Keywords: artificial tears, dry eye, safety, efficacy, carboxymethylcellulose 0.5%/glycerin 0.9%, sodium hyaluronate 0.18%

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Purification and in vitro antioxidant activities of tellurium-containing phycobiliproteins from tellurium-enriched Spirulina platensis

Yang F, Wong KH, Yang YF, Li XL, Jiang J, Zheng WJ, Wu HL, Chen TF

Drug Design, Development and Therapy 2014, 8:1789-1800

Published Date: 9 October 2014

Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes

Mulvey JJ, Feinberg EN, Alidori S, McDevitt MR, Heller DA, Scheinberg DA

International Journal of Nanomedicine 2014, 9:4245-4255

Published Date: 4 September 2014

Fluorescence resonance energy transfer-based real-time polymerase chain reaction method without DNA extraction for the genotyping of F5, F2, F12, MTHFR, and HFE

Martinez-Serra J, Robles J, Nicolàs A, Gutierrez A, Ros T, Amat JC, Alemany R, Vögler O, Abelló A, Noguera A, Besalduch J

Journal of Blood Medicine 2014, 5:99-106

Published Date: 25 June 2014

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Thrombin use in surgery: an evidence-based review of its clinical use

Sung W Ham, Wesley K Lew, Fred A Weaver

Journal of Blood Medicine 2010, 1:135-142

Published Date: 22 July 2010