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Evaluation of Anthelminthic Activity of Tropical Taniferous Plant Extracts Against Haemonchus contortus

Authors Birhan M, Gesses T, Kenubih A, Dejene H, Yayeh M

Received 1 August 2019

Accepted for publication 11 September 2020

Published 20 October 2020 Volume 2020:11 Pages 109—117

DOI https://doi.org/10.2147/VMRR.S225717

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Young Lyoo


Mastewal Birhan,1 Tilahun Gesses,1 Ambaye Kenubih,1 Haileyesus Dejene,2 Muluken Yayeh1

1Department of Veterinary Paraclinical Studies, College of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Veterinary Epidemiology and Public Health, College of Veterinary Medicine and Animal Science, University of Gondar, Gondar, Ethiopia

Correspondence: Mastewal Birhan Email maste675@gmail.com

Introduction: The present trial aimed to investigate invitro anthelminthic activities of selected tropical tanniferous plant extract on egg hatchability and larval development inhibition of Haemonchus contortus in sheep. In view of that, three tropical tanniferous plants Rhus glutinosa, Syzygium guineensa and Albizia gumifera, were selected based on their relative high content of condensed tannins.
Methods: In this study, eggs were collected from artificially infected with H. contortus. Then the egg was directly subjected to invitro assay with these condensed tannin-enriched extracts using egg hatchability assay and inhibition of larval development assay.
Results: The result showed that extracts from all three tropical tanniferous plants demonstrated statistically significant (P < 0.05) dosedependent inhibition of both egg hatchability and larval development. According to IC50 and IC90 values, the condensed tannin-enriched extracts inhibiting egg hatching and larval development most potently were Rhus glutinosa followed in descending order of activity by Syzygium guineensa and Albizia gumifera.
Discussion: The result of this study showed that these condensed tanninenriched extracts were effective in inhibiting egg hatchability as well as larval development. Therefore, condensed tannin might be recommended as one of the options for the control of H. contortus in sheep.

Keywords: Haemonchus contortus, condensed tannin, anthelmintic, larval development assay, egg hatchability assay

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