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Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Authors He Z, Su C, Bi Y, Cheng Y, Lei D, Wang F

Received 4 November 2020

Accepted for publication 13 January 2021

Published 10 February 2021 Volume 2021:14 Pages 489—496

DOI https://doi.org/10.2147/IDR.S289885

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Héctor Mora-Montes


Zhengxin He,1,* Chang Su,2,* Yuwang Bi,3 Yan Cheng,1 Daxin Lei,1 Fukun Wang1

1Laboratory Medicine, The 980th Hospital of PLA Joint Logistical Support Force (Bethune International Peace Hospital), Shijiazhuang, Hebei, 050082, People’s Republic of China; 2Cardiothoracic Surgery, The 980th Hospital of PLA Joint Logistical Support Force (Bethune International Peace Hospital), Shijiazhuang, Hebei, 050082, People’s Republic of China; 3Information Center, The 980th Hospital of PLA Joint Logistical Support Force (Bethune International Peace Hospital), Shijiazhuang, Hebei, 050082, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Chang Su; Fukun Wang Tel +8631187978349; +8631187978537
Email suchang987@163.com; wangfk8@sina.com

Background: Since urine cultures are only guaranteed for patients with obvious urinary symptoms in most cases, most of candiduria episodes are ignored in clinic.
Objective: This study aimed to design a screening protocol to improve diagnostic efficiency of candiduria, and provide information of Candida species and drug susceptibility.
Methods: All patients, who were admitted to the intensive care unit (ICU) of our hospital during December 1, 2018 and October 1, 2019, were enrolled in this study. Urinalysis was performed every three days for each subject from the first day of ICU admission. Urine specimens were sampled for fungal culture with either condition: (1) yeast-like cell counting (YLCC) ≥ 200; (2) positive YLCCs were observed in two consecutive tests, and at least one YLCC ≥ 100.
Results: The screening protocol dramatically improved the candiduria diagnostic rate of ICU patients from 2.28% to 17.27%. However, compared to the historical control, the screening protocol has no time-saving advantage in candiduria diagnosing. Higher percentage of C. albicans in screening protocol-identified candiduria patients was observed, although there was no statistical difference. Our results indicated that female gender, pneumonia, diabetes and infarction/hemorrhage patients were more prone to develop candiduria. Non-candiduria patients showed a better tendency for survival and shorter ICU stay length. Multisite colonization was common in the surveyed candiduria patients, who were up to 70.83% showed Candida positive cultures in sputum.
Conclusion: The screening protocol established in the study was a convenient and practical tool for early warning and feasible management of candiduria and IC.

Keywords: candiduria, intensive care unit, screening protocol, urinalysis, yeast-like cell counting

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