Back to Journals » Neuropsychiatric Disease and Treatment » Volume 15

Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis

Authors Koraysha NA, Kishk N, Hassan A, Samy El Gendy NM, Shehata HS, Al-Azayem SA, Kamal YS

Received 17 May 2019

Accepted for publication 14 August 2019

Published 6 September 2019 Volume 2019:15 Pages 2571—2578


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Noha Abo Koraysha,1 Nirmeen Kishk,1 Amr Hassan,1 Nehal M Samy El Gendy,2 Hatem S Shehata,1 Salsabil Abo Al-Azayem,1 Yasmine Shawki Kamal1

1Neurology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt; 2Ophthalomology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt

Correspondence: Nehal M Samy El Gendy
Ophthalomology Department, Kasr Al Ainy Hospital, Cairo University, 43th Gameat El Dewal Street, Cairo 12411, Egypt
Tel +20 100 108 5164

Background and purpose: The development of new biomarkers for multiple sclerosis (MS) is of paramount importance to improve our ability to predict disease progression and disability. The aim of this study was to evaluate the potential role of the optic nerve diameter (OND) measured by ultrasonography as a biomarker of early disability in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods: Forty-nine RRMS patients, 23 with a history of optic neuritis (MS-ON) and 26 without a history of optic neuritis (MS N-ON), and 50 age- and sex-matched healthy control subjects were included in the study. The OND and optic nerve sheath diameter (ONSD) were measured by transorbital sonography (TOS), and the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thicknesses were measured by optical coherence tomography (OCT) using the Optovue RTVue™ system (Optovue, Inc., Fremont, CA, USA).
Results: There was no significant difference between the patient (whether ON or N-ON eyes) and control groups in either the OND (p=0.979) or the ONSD (p=0.911). However, patients with an expanded disability status scale (EDSS) score >2 had a significantly lower OND and RNFL thicknesses (p=0.014, p=0.010 respectively) than patients with an EDSS score ≤2. Statistical logistic regression revealed that OND was an independent predictor of EDSS>2 (p=0.044, OR =0.000, 95% CI=0.000–0.589).
Conclusion: The OND, as measured by ultrasonography, could be potentially used as a biomarker for the detection of early disability in RRMS patients.

Keywords: multiple sclerosis, biomarker, OCT, transorbital sonography, RNFL

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]