Essential nutrient requirements of the elderly

Introduction

Energy expenditure decreases with advancing age at a rate of about 150 kcal per decade,¹ and is accompanied by a decrease in energy consumption. Other than a decrease in caloric needs, there is no evidence that older individuals have lower nutrient needs, and in some cases nutritional requirements increase. Meeting these requirements may require consumption of more nutrient dense foods. Chronic illness, loss of appetite, and inability to access food often present further challenges to meeting the nutritional needs of the older adults.

A number of agencies have established guidelines for nutritional requirements. The estimated average requirement (EAR), the amount at which half of the group will require less, and the other half more, is a relatively universal term. The recommended daily allowance (RDA) is set two standard deviations above the EAR, so that it meets the nutritional requirements of 97% to 98% of the population and can be regarded as a goal.² The RDA (as it is known in Canada, the United States, and Japan) is known as the RDI (recommended daily intake) in Australia and New Zealand;³ and RNI (reference nutrient intake) in the United Kingdom.⁴

Vitamins

There is general agreement on recommended nutrient requirements between medical organizations. Most clinically overt deficiencies are uncommon in industrialized countries. Those at risk for micronutrient deficiency are also at risk for overall nutritional deficiency, and so micronutrient deficiencies may present concomitantly, in a nonspecific manner, and be difficult to diagnose. Readily available laboratory testing only exists for folate, vitamin B12, and vitamin D.

Requirements for niacin, vitamin C, biotin and pantothenic acid do not appreciably change with advancing age. These, along with all elderly nutritional requirements have been extensively reviewed recently.⁵

Vitamin A

The RDA for vitamin A is the same for older and younger adults. Older adults may absorb supplemental vitamin A more efficiently than younger adults (<60 years), even the elderly with low vitamin A intake (below current recommendations) have normal vitamin A levels. The RDA for vitamin A is the same for older and younger adults, 900 and 700 mcg retinol activity equivalents (RAE) for men and women, respectively. Although average intakes in the U.S. are below these recommendations, vitamin A deficiency is rare,⁶ and concerns about hypervitaminosis may may outweigh those of deficiency.⁷ Epidemiologic data show that populations with high levels of vitamin A intake are at increased risk for osteoporotic fractures,⁸ although possibly only in those who are deficient in vitamin D.⁹ The tolerable upper limit intake (UL) for vitamin A is 3,000 mcg per day.

Thiamine (vitamin B1)

Thiamine requirements do not change with age. Prior to thiamine fortification of grain products, low levels were seen commonly in older people. For example, 43% of 224 elderly people had thiamine levels below the fifth percentile of younger people in a New Zealand study, and lower levels correlated with age rather than comorbidities.¹⁰ Malabsorption of thiamine is seen in individuals who consume significant amounts of alcohol. In people with a history of alcohol abuse vitamin supplements, even in countries where grain products are fortified with thiamine, those patients with a history of alcohol abuse may need vitamin supplements to bring thiamine levels closer to those who are non-alcohol dependent.¹¹

Congestive heart failure (CHF) is common in elderly patients, and is often accompanied by inadequate nutritional intake. As most CHF patients will be treated with loop diuretics, the hyper excretion of thiamine caused by loop diuretics places these patients at particular risk for thiamine deficiency.¹² The prevalence of thiamine deficiency in CHF has been stated to be from 21% to 98%.¹³ Several small RCTs involving less than 50 patients have demonstrated improvement in cardiac parameters in patients who received thiamine supplements.¹³

Riboflavin

Riboflavin functions as a coenzyme in numerous redox reactions and in energy production. Daily requirements (1.3 mg in men, 1.1 mg in women) do not diminish with age even though the elderly have lower energy expenditure.¹⁴

In Australia and New Zealand the recommended intake for riboflavin for patients over the age of 70 years of age is slightly higher (1.6 mg for men, 1.3 mg for women), based on biochemical evidence of deficiency in 12% of non-institutionalized elderly in a study conducted in the United Kingdom.¹⁵

Vitamin B6

There is no defined vitamin B6 deficiency disease, however, vitamin B6 is a cofactor in many enzymatic reactions, and its deficiency may have wide ranging effects and present with non-specific clinical manifestations. Experimentally, vitamin B6 deficiency impairs interleukin 2 production and depresses the response of lymphocytes to mitogen stimulation.¹⁶ Vitamin B6 deficiency variably correlates with various cancers, cardiovascular disease and cognitive decline, and several studies show a high prevalence of vitamin B6 deficiency in the elderly.¹⁷

Most daily recommendations for vitamin B6 for adults range from 1.2 to 1.4 mg, although recommendations are higher (1.7 mg for men, and 1.5 mg for women) for adults over the age of 50 years in the United States, Canada, Australia, and New Zealand, due to evidence that 1.90 mg per day was needed to normalize biochemical evidence of deficiency in twelve patients over the age of 60 years.¹⁸ The levels of plasma pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, are probably the best indicator of vitamin B6 status. While setting target levels of PLP at 20 nmol/L may overestimate B6 requirements, this level provides a safety margin to protect against symptoms of deficiency, and so is considered optimal.¹⁴ National Health and Nutrition Examination Survey (NHANES) 2003 to 2004 data show that even at intakes of 2.0 to 2.9 mg per day, 14% of those over the age of 65 years in the United States had levels of PLP <20 nmol/L.¹⁹ The UL for vitamin B6 is 100 mg per day.

Vitamin B12

Naturally occurring vitamin B12 is only found in foods of animal origin, such as meat, eggs, and dairy products. The RDA for adults living in Australia, New Zealand, Canada, and the United States, for vitamin B12 is 2.4 mcg, with slightly lower recommended intakes in other industrialized nations. Median dietary intakes in these countries exceed the RDA, and about 5% of older patients are deficient.²⁰ When deficiency does occur, it is usually due to malabsorption rather than inadequate intake. Often the elderly will have an age-associated decrease in parietal cell activity with an attendant loss of secretion of gastric acid needed to cleave vitamin B12 from the proteins to which it is bound. When this occurs, intrinsic factor is unable to bind to vitamin B12 and malabsorption ensues. Elderly patients with vitamin B12 malabsorption will maintain the ability to absorb the crystalline vitamin B12 found in supplements and added to fortified foods, subsequently, Health Canada and the Institute of Medicine (IOM) both recommend that patients over the age of 50 years include vitamin B12-fortified foods in their diet, or take vitamin B12 supplements.^6,21

Adequate cobalamin status

Serum B12 levels are easily measured and correlate with deficiency. Vitamin B12 deficiency will result in accumulation of homocysteine and methylmalonic acid, the latter of which is specific to vitamin B12 deficiency, subsequently, elevated methylmalonic acid levels can be used to diagnose vitamin B12 deficiency in patients with borderline low vitamin B12 levels, which may be seen in over 20% of patients over the age of 60.²⁰

Deficiency

Vitamin B12 deficiency can result in a wide array of neurologic manifestations, although most patients with low vitamin B12 levels are asymptomatic. Patients may present with vague cognitive or psychiatric symptoms, and with the absence of the classic hematologic findings like anemia or macrocytosis, may be difficult to diagnose.²² Low vitamin B12 levels are a risk factor for cognitive decline,²³ but treating patients with borderline low levels does not improve cognitive function.²⁴

Approach to the patient

No medical organizations recommend routine screening of patients for vitamin B12 deficiency, although, given the high prevalence of low vitamin B12 levels, along with subtle manifestations of deficiency, clinicians should be alert to the possibility of vitamin B12 deficiency. Elderly patients should consume crystalline B12, either in the form of supplements or fortified foods, and for those who do not, particularly those with risk factors for malabsorption, such as prior gastric surgery, history of taking H2-blockers, proton pump inhibitors, or metformin, there should be a low threshold for laboratory investigation of vitamin B12 levels. Daily supplement intake as high as 10,000 times the RDA (30 mg) has been shown to be safe.²⁵

Folate

There is no evidence that folate requirements change with advancing age. The RDA for folate in the United States, Canada, New Zealand and Australia for men and women is 400 mcg; 240 mcg in Japan, and 200 mcg in the United Kingdom.^2,4,6,21 In order to decrease the number of children born with neural tube defects, many governments mandate folic acid fortification of grain products. In the United States, following folic acid fortification in 1998, mean folate concentrations rose from 4.6 to 10.0 ng/mL, and the prevalence of low folate concentrations decreased from 22% to 1.7% in adults.²⁶ Folate levels can readily be ascertained through available blood tests.

Vitamin D

The effect of ultraviolet (UV) light on 7-dehydrocholesterol found in the dermis and epidermis initiates a reaction which results in the formation of vitamin D (cholecalciferol, D3), a pro-hormone, which is converted to the active 1,25-dihydroxy-cholecalciferol.²⁷ Because of lifestyle factors which result in low levels of UV exposure, vitamin D3 deficiency has become common, and for many people dietary consumption is now the primary means of vitamin D3 acquisition, particularly for older persons in institutional settings.²⁷ As vitamin D3 is not naturally found in many foods, those foods supplemented with vitamin D3 (milk products, fortified cereals) are an important source.²⁷ Oral supplementation has become routine, particularly for institutionalized elderly people.²⁷

Vitamin D requirements

Vitamin D requirements are based on those intakes needed to maintain serum levels. Vitamin D is hydroxylated in the liver to 25-hydroxy-vitamin D [25(OH)D3], the levels of which correlate with vitamin D status. The definition of vitamin D sufficiency, a serum level of 75 nmol/L (30 ng/mL), is based on levels of parathyroid hormone and biological evidence of bone health. Desired vitamin D levels for other health outcomes, such as cancer and cardiovascular disease prevention, are unknown, however there is as yet no hard evidence that higher levels are beneficial. Also, the implications of low levels may be different for different ethnic groups. For example, low levels of 25(OH)D3, commonly seen in black Americans may reflect genetic polymorphisms affecting levels of vitamin D binding protein instead of true deficiency.³¹ Because older skin loses some ability to manufacture vitamin D, and because the elderly are indoors more often, the elderly are at higher risk for vitamin D deficiency. Recommendations for vitamin D intake vary, in part due to variation in UV light available at different latitudes, but also based on differing conclusions reached from available data, and are listed in Table 1.

Table 1 Recommended adult vitamin D intake Notes: *Adequate intake, No RDA exists; **1 mcg =40 IU. Abbreviation: RDA, recommended daily allowance.

Both Health Canada and the IOM note that the primary source for vitamin D is fortified foods, and not sun exposure. In addition to obtaining vitamin D through food sources, Health Canada recommends that all adults over the age of 50 years consume a 400 IU (10 mcg) supplement each day.³¹

Current intakes

In the United States, because it is more common for women to take vitamin D3 supplements in conjunction with calcium supplements, intakes are higher in women than men.²⁷ For females aged 51 to 70 years, median vitamin D3 intake was 308 IU daily, and for women over the age of 70 years, 356 IU (160 IU from food, 196 IU from supplements).²⁷ The ninety-fith percentile for vitamin D intake was 586 IU per day for men, and 940 IU per day for women, well below the UL of 4,000 IU per day. Under optimal conditions the human body can manufacture up to 10,000 IU a day,³³ and in one balance study conducted over two years, vitamin-replete middle-aged men in Nebraska were estimated to utilize approximately 4,000 IU vitamin D3 daily.³⁴

Fall and fracture prevention

A meta-analysis of ten trials conducted in 2010 showed a 14% reduction in fall risk, with community dwellers over the age of 80 years, and persons taking at least 800 IU (20 mcg) daily benefitting the most. Falls were reduced by 14%.³⁵

There is consensus that vitamin D supplements decrease fracture risk in the elderly. A 2005 meta-analysis concluded that the ability of vitamin D to prevent non-vertebral fractures is dose-dependent, and that patients prescribed at least 700 to 800 IU (17.5 to 20 mcg) vitamin D daily had a 26% decrease in hip fractures, and a 23% decrease in nonvertebral fractures, while 10 mcg daily did not improve outcomes.³⁶ Two subsequent meta-analyses by the same authors involving over 40,000 patients showed similar findings.^37,38

Other health outcomes

Observation data suggest vitamin D insufficiency has a role in many adverse health outcomes, including cancer, and heart disease,^39,40 however there are no randomized controlled trials (RCTs) demonstrating health benefits other than fall or fracture prevention as of yet.

Summary and recommendations

Vitamin D deficiency (serum levels of 25[OH]D <50 nmol/L [20 ng/mL]) is common among elderly patients and is associated with adverse consequences. Irrespective of serum levels, elderly patients who are at risk of falling who take vitamin D3 supplements at doses of 800 IU (20 mcg) daily have a decreased risk of falls and fractures. Other health benefits have not been supported by RCTs yet. Vitamin D intake of up to 4,000 IU (100 mcg) daily is safe, and serum levels of 25(OH)D3 can be used to guide clinical decision making.

Because of the high prevalence of vitamin D deficiency in elderly adults, many clinicians consider either universal supplementation or universal screening for vitamin D deficiency. Both strategies were considered cost effective in a mathematical model of elderly patients in the United States. Screening for vitamin D deficiency was considered to be more cost effective (rather than empiric supplementation with 25 mcg daily) in those over the age of 80 years, in whom 25 mcg daily may be inadequate to normalize serum levels.⁴¹

Vitamin E

The RDI of vitamin E is 15 mg for all adults, and most adults have normal levels.^42,43 Because of its role as an antioxidant, vitamin E has been studied in degenerative diseases. While diets which are high in vitamin E are associated with lower mortality from coronary artery disease (CAD),⁴⁴ RCTs have not demonstrated that vitamin E supplements lower the risk of CAD.^45,46 Similarly, while dietary vitamin E consumption is associated with lower rates of cognitive decline,⁴⁷ high dose supplements (2,000 IU per day) have not been shown, in patients with mild cognitive impairment who are at high risk for developing Alzheimer’s disease, to decrease the risk for such progression.⁴⁸ In contrast, a recent RCT showed high doses of vitamin E (2000 IU per day) to mildly slow functional decline in patients already diagnosed with mild to moderate Alzheimer disease over one year.⁴⁹

Vitamin K

Vitamin K is found in green leafy vegetables, and its intake varies widely. The RDA for vitamin K is approximately 1 mcg per kg of body weight, (90 mcg and 70 mcg respectively for adult men and women), and is based on the amount needed for normal functioning of the clotting cascade. It is uncertain whether this amount is sufficient for adequate synthesis of other vitamin K-dependent proteins. For example, osteocalcin is a protein produced by osteoblasts which has a role in bone mineralization, the activity of which is determined by its level of vitamin K-dependent carboxylation. Studies have correlated a higher fracture rate with under-carboxylated osteocalcin. Since vitamin K intakes reported for the general population do not ensure complete carboxylation of osteocalcin, vitamin K requirements for bone function may be higher than what is needed to maintain hemostasis.^50,51 Women in the lowest quintile of vitamin K intake (<109 mcg per day) had a 1.43 relative risk of hip fractures compared with the other quintiles in the Nurses’ Health Study,⁵² and in the Framingham Heart Study those in the highest quartile of intake (median 254 mcg per day) had a 0.35 relative risk for hip fractures compared with those in the lowest quartile (median intake 56 mcg per day).⁵³ However, if vitamin K intake is critical for bone health, then the use of warfarin, a vitamin K antagonist, might be expected to have a negative effect on bones. While findings have been inconsistent, warfarin does not appear to cause clinically significant bone loss or an increased risk of fractures,^51,54 and the understanding of the role of vitamin K in skeletal health is still evolving.

Water

The daily water intake required for adults is about 30 mL per kg, or about 1,500 to 2,500 mL. The percentage of whole body water decreases modestly with age, hence, loss of fluid is more significant in the elderly. When confronted with dehydration, the elderly kidney, even in the absence of disease, loses some ability to conserve water because of a loss in concentrating ability, which is predicted by the formula: maximal urine osmolarity =1,134 mOsm per kg − (4 mOsm per kg × age).⁵⁵ An 80-year-old kidney, for example, will only maximally concentrate to 800 mOsm per L, and, given a daily required urinary osmolar output of 800 mOsm, will have an additional obligatory 250 to 300 mL daily fluid loss compared to a young kidney. Minimum water requirements are therefore modestly higher in the elderly.

Protein

According to nitrogen balance studies, healthy adults have an average minimum dietary protein requirement of 0.66 g per kg of ideal body weight, and a calculated RDA of 0.8 g per kg. This recommendation is the same for both young and older adults.^56,57 While appropriate for establishing the minimum amount of protein required for short term homeostasis, balance studies are not designed to determine optimal clinical outcomes,³ and a number of authors have suggested that the protein requirement for the elderly should be increased to 1.0 to 1.2 g per kg per day or higher,^58,59 and recommendations for protein intake for adults over the age of 70 years in Australia and New Zealand have been raised to a level 25% higher than those for younger adults.⁶⁰ Observational data suggest improved health outcomes in the elderly who have higher protein intakes. The Health Aging and Body Composition (Health ABC) study showed that in persons 70 to 79 years of age, over a three-year period, those in the highest quintile of protein intake lost 40% less lean body mass compared with those in the lowest quintile.⁶¹ Another longer term nitrogen balance study showed that patients consuming the RDA for protein over a 14-week period lost mid-thigh muscle mass, suggesting that muscle strength may be at risk for patients consuming the current recommended protein intake.⁶²

Unfortunately, supplementing frail elderly patients with protein and calories does not reflexively improve clinical outcomes. A review of nutritional supplements in 62 trials involving over 10,000 patients showed modest improvements in weight and mortality, primarily in those who were malnourished, with most trials showing no benefit of routine supplementation.⁶³

Dietary protein to enhance anabolism

While the precise mechanisms are not completely understood, there is an imbalance between the synthesis and breakdown of muscle protein that accompanies aging, and the resultant progressive muscle weakness will invariably result in some degree of functional decline.⁶⁴ In part this may be because aging muscle is less sensitive to the stimulant effect that dietary protein has on protein synthesis, so that higher levels of protein intake are required in the elderly to stimulate muscle anabolism. Specific feeding strategies may enhance this stimulation. “Fast” proteins, such as whey, stimulate muscle protein synthesis⁶⁵ more than “slow” proteins, such as casein. Essential amino acids, particularly leucine, bind to receptors which stimulate muscle protein synthesis; and adding leucine to protein supplements increased the rate of muscle protein synthesis in ten elderly men in an RCT.⁶⁶ Because age is associated with decreased chewing efficiency, even changes in food consistency may play a role in protein balance by increasing the rate at which amino acids from dietary protein enter the circulation. Whole body protein balance was more positive after ingesting minced beef than beef steak in ten elderly men.⁶⁷

Potential negative impact of increasing dietary protein

Osteoporosis

Increasing dietary protein does result in a higher urinary calcium excretion, which, if due to calcium buffering acids generated from protein metabolism, could predispose to osteoporosis. However, higher protein intakes improve intestinal calcium absorption, and increase calcium retention, especially when calcium intake is low.⁶⁸ Epidemiologic data also support improved skeletal health with higher protein intakes.⁶⁹

Kidney disease

Higher protein intakes cause hyperfunctioning of the glomerular basement membrane which results in worsening proteinuria. Protein intake of 1.1 g per kg does not appear to reduce renal function in elderly patients with normal renal function.⁷⁰ For patients with kidney disease, the National Kidney Foundation has established guidelines for protein intake, and recommends 0.60 to 0.75 g per kg for patients with a creatinine clearance <25 mL per minute. Patients on chronic dialysis require a higher amount of protein and should receive 1.2 g per kg daily.⁷¹

Exercise

Dietary protein is more effective at stimulating muscle anabolism when accompanied by resistance exercises. Meta-analysis suggests that in older (62 years ±6 years) patients both fat-free mass and strength gains from resistance exercises are augmented by protein supplementation, even in patients already consuming adequate amounts of protein.⁷² Protein supplements alone (15 g added to breakfast and lunch) did improve physical performance in an RCT of 65 frail elderly (average age 78) who were already consuming on average 65 g of protein per day.⁷³ When prolonged resistance-type exercise training was added twice weekly for 6 months, an increase in lean body mass was observed.^73,74

Calcium

In the United States the lifetime incidence of fragility fractures approaches 40% in women and 10% in men. Since nearly 99% of the calcium content of the human body is contained in the skeleton, it makes sense that an adequate calcium intake should be an important part of the nutritional plan for most elderly, and almost 70% of postmenopausal women in the United States take calcium supplements.⁷⁵

Calcium recommendations

A quarter of a century ago Kanis and Passmore argued against the use of calcium supplements, questioning the relevance of balance studies in defining an adequate calcium intake, and noting that low levels of calcium intake stimulate more efficient intestinal absorption.⁷⁶ Since this intestinal adaptation may take months to occur, short term balance studies, they argued, may underestimate the efficiency of calcium absorption, and so overestimate calcium requirements.⁷⁶ Despite being difficult to perform, balance studies continue to be an important component in calculating calcium requirements.²⁷ Confounding variables include the variability of calcium absorption from different foods and supplements, the effects that other dietary factors such as protein and salt have on calcium absorption, and especially the presence or absence of vitamin D deficiency.²⁷ The high prevalence of osteoporosis in the US alone argues for high calcium intakes, yet the ability of an increased calcium intake to overcome the effects of bone loss related to aging continues to be debated.²¹ Compared with younger adults, current United States recommendations for calcium intake are modestly higher for women and persons over the age of 70 years. For most people, achieving these levels will necessitate ingesting dietary supplements. Recommendations from other organizations are similar (Table 2). The RDA for calcium in Japan is lower than most other industrialized countries, and Japanese women consume less calcium than those in the United States, (400 mg versus 650 mg) yet have a lower rate of hip fractures.⁷⁷

Table 2 Recommended daily allowances (RDA) for calcium in representative countries

Calcium and osteoporosis

For over 20 years studies have pointed to modest increases in bone density in patients taking calcium supplements. An RCT of 301 healthy postmenopausal women in 1990 demonstrated that 500 mg daily elemental calcium supplementation lessened bone loss over 2 years, but primarily in women who had a prior calcium intake of <400 mg per day.⁷⁸ Postmenopausal women receiving higher doses (1,000 mg per day) of calcium supplements for 2 years had similar improvements in bone density, even when they had had higher calcium intakes prior to enrollment.⁷⁹

Recent trials on fracture prevention have often included supplementing subjects with both calcium and vitamin D, which tends to obscure the individual role of calcium in fracture prevention. In a prospective cohort study of 61,433 Swedish women followed for up to 19 years, fracture rates were highest for those in the lowest quintile of calcium intake. In this group, fracture rates were similar for the other four quintiles, suggesting that in this population, calcium supplements may be indicated for those only at the lowest intake levels.⁸⁰ A meta-analysis of RCTs involving 1,806 patients from 2002 concluded that calcium supplements have a small positive effect on bones, with a 2% increase in bone density, and that the risk of vertebral and non-vertebral fractures was decreased, but not to a statistically significant degree.⁸¹ A larger meta-analysis involving over 63,000 patients concluded that with regard to calcium, supplements did lower fracture rates, and that rates were most improved with supplement doses >1,200 mg per day, in patients with low vitamin D levels, in patients with a low baseline calcium intake (<700 mg per day), and in patients over 70 years of age.⁸²

Other effects of calcium

Calcium supplements may increase the risk for kidney stones.⁸³ Recent evidence suggests a possible negative effect on coronary heart disease. An RCT involving 1,471 patients taking calcium or placebo for 5 years showed a significant increase in myocardial infarction in the treatment group,⁸⁴ though no adverse cardiac events were seen from calcium and vitamin D supplementation in the Women’s Health Initiative.⁸⁵ In over 60,000 women in the Swedish mammography cohort followed on an average for 19 years, those women with calcium intakes over 1,400 mg daily had significantly higher all-cause mortality.⁸⁶

Iron

Iron requirements for premenopausal women are more than twice that for men, but after the age of menopause those requirements decrease so that requirements are the same for both sexes. Iron deficiency in the elderly is more commonly the result of illness than inadequate intake.

Zinc

Recommended intakes for zinc are the same for older and younger adults. According to the IOM the RDA is 8 mg for women and 11 mg for men.⁵⁰ In the United States, where patients commonly take dietary supplements, 35% to 45% of elderly adults had inadequate dietary intakes, and even in those elderly consuming dietary supplements, 20% to 25% may not meet the RDA.⁸⁷ Twenty frail homebound elderly in the United Kingdom were found to be in negative zinc balance with mean daily intakes of 6 mg (90 mmol). Zinc intakes correlated best with protein and energy intakes.⁸⁸

Zinc is required in over 300 enzymatic reactions, so the consequences of zinc deficiency may be widespread; however, the diagnosis of zinc deficiency is difficult. Even abnormalities of taste, seen characteristically in zinc deficiency, may be a poor marker of zinc status.⁸⁹ Zinc levels are not routinely ordered in clinical practice, and diagnosis is complicated by a lack of reliable laboratory markers.⁹⁰

A decrease in T-cell medicated immunity is seen in both senescence and zinc deficiency. In 617 patients in Boston nursing homes who had low serum zinc concentrations (<70 mcg/dL) there was higher incidence of pneumonia, antibiotic use, and all-cause mortality.⁹¹ Zinc supplementation, (zinc gluconate given as 45 mg of elemental zinc daily) in 50 healthy older adults reduced the incidence of minor illnesses over 1 year, while lowering levels of inflammatory cytokines.⁹² Because of the role of zinc in the immune system, some suggest zinc supplementation for all hospitalized patients.⁹³

Conclusion

Although through efficient absorption of calcium the body can maintain an adequate calcium balance at various intakes, most organizations place the optimal daily calcium intake at 1,000 to 1,200 mg. Calcium balance studies generally support this level of intake. Positive effects from increasing calcium intakes are more likely to be seen in those with low intakes. In the absence of significant dairy consumption (250 cc milk contains about 300 mg elemental calcium), to achieve these recommended intakes, most adults will need to ingest calcium supplements, the effects of which have recently been reviewed.⁹⁴

There are significant differences in the recommended calcium intakes from different organizations, even when the populations are from similar ethnic origins (United Kingdom and Australia/New Zealand). United States Preventative Services Task Force recently made recommendations regarding calcium and vitamin D supplements for the prevention of falls and fractures, and recommended against using calcium supplements in doses <1,000 mg (and <400 IU vitamin D), while noting that there are insufficient data regarding calcium supplements in doses >1,000 mg per day and vitamin D >400 IU.⁹⁵

Disclosure

The author reports no conflicts of interest in this work.

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