Back to Journals » Degenerative Neurological and Neuromuscular Disease » Volume 7

Erythrocyte membrane in the evaluation of neurodegenerative disorders

Authors Sadanand A, Janardhanan A, Sankaradoss A, Vanisree AJ, Arulnambi T, Bhanu K

Received 14 June 2017

Accepted for publication 1 September 2017

Published 17 October 2017 Volume 2017:7 Pages 127—134


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Thomas Müller

Anjana Sadanand,1 Anjali Janardhanan,1 Arun Sankaradoss,1 Arambakkam J Vanisree,1 Thamilpavai Arulnambi,2 Kesavamurthy Bhanu2

1Department of Biochemistry, University of Madras, 2Department of Neurology and Neurosurgery, Madras Medical College, Chennai, India

Abstract: Neurodegenerative diseases have many similar pathological conditions, and very few studies exist which detail their molecular features. Proteins like Na+/K+-ATPase (NKA), α-spectrin (SPTA) and drebrin have been reported to be involved in the integrity of neuronal cell membrane and their functions. Furthermore, recent studies have highlighted their implication in neurodegeneration. In the current study, we wanted to identify the role of NKA, SPTA and drebrin in the erythrocyte membranes obtained from the blood of patients with neurodegenerative disorders (NDs) subjected to motor impairment such as Parkinson’s disease, amyotrophic lateral sclerosis, ataxia and dementia. We have studied the activity of NKA and the expression of NKA, SPTA and drebrin in the erythrocyte membrane by quantitative real-time PCR and Western blot obtained from the blood samples of patients with NDs culminating in movement and memory dysfunction. We observed a significant reduction in the expressions of NKA, SPTA and drebrin when compared to control and significant variations among the recruited ND samples. On correlating, we found a significant relationship between the expressions and the clinical features such as bradykinesia. Thus, we suggest that the reduction in the expressions of NKA, SPTA and drebrin could function as tools of assessment and speculate the particular neurodegenerative condition.

Keywords: Na+/K+-ATPase, spectrin, drebrin, neurodegeneration and movement disorder

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]