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Eribulin in the management of inoperable soft-tissue sarcoma: patient selection and survival

Authors Thomas C, Movva S

Received 29 February 2016

Accepted for publication 7 July 2016

Published 9 September 2016 Volume 2016:9 Pages 5619—5627

DOI https://doi.org/10.2147/OTT.S93517

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr William Cho


Colin Thomas, Sujana Movva

Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA

Abstract: Patients diagnosed with metastatic soft-tissue sarcoma (STS) have a poor prognosis. Additionally, after failure of first-line therapy, there are relatively few treatment options from which to choose. The novel tubulin-binding drug, eribulin, with a unique mechanism of action from taxanes or vinca alkaloids, has shown clinical activity in several different types of cancers. Eribulin has been approved by the US Food and Drug Administration (FDA) for patients with metastatic breast cancer previously treated with an anthracycline or a taxane and has recently been FDA approved for patients with unresectable or metastatic liposarcoma who have failed a previous anthracycline regimen. Here, we review current standard treatments of STS, a background of eribulin, the studies that have propelled eribulin to FDA approval for liposarcoma, and future directions of the drug. The benefits of eribulin in STS are discussed in detail, especially with regard to the recent pivotal Phase III study comparing eribulin to dacarbazine for leiomyosarcoma and adipocytic sarcoma.

Keywords: eribulin, tubulin-binding drugs, soft-tissue sarcoma

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