Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence
Received 28 May 2020
Accepted for publication 25 August 2020
Published 11 September 2020 Volume 2020:12 Pages 977—987
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Eyal Cohen
Ming-Szu Hung,1– 3 Yi-Chuan Chen,2,4 Tsung-Yu Huang,5– 7 Dong-Ru Ho,6,8,9 Chuan-Pin Lee,10 Pau-Chung Chen,11,12 Yao-Hsu Yang10,13,14
1Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan; 2Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan; 4Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan; 5Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan; 6Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 7Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan; 8Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan; 9Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan; 10Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan; 11Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; 12Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan; 13Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan; 14School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Correspondence: Yao-Hsu Yang Email firstname.lastname@example.org
Background: Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery.
Methods: From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI).
Results: The incidence of ED was higher in the lung cancer cohort compared to the non-lung cancer cohort (38.47 vs 28.28 per 10,000 person-years) with an adjusted IRR (aIRR) of 1.34 (95% CI: 1.06– 1.70, p=0.014) after the confounders were adjusted for. An increased incidence of ED was observed in the lung cancer cohort aged 40– 54 years (aIRR: 5.44, 95% CI: 2.25– 13.15, p< 0.001), 55– 64 years (aIRR: 3.62, 95% CI: 1.61– 8.17, p=0.002) years, and anxiety (aIRR: 2.99, 95% CI: 1.81– 4.94, p< 0.001). In addition, a higher incidence of emergency room (ER) visits (aIRR: 2.19, 95% CI: 1.98– 2.42, p< 0.001) was observed in lung cancer patients with ED compared to those without ED.
Conclusion: Our study results suggested that early surveillance and intervention of ED should be advocated in lung cancer patients after surgery.
Keywords: lung cancer, surgery, erectile dysfunction
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