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Epstein–Barr virus-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement

Authors Saito M, Morioka M, Izumiyama K, Mori A, Irie T, Tanaka M, Matsuno

Received 3 May 2012

Accepted for publication 8 June 2012

Published 23 August 2012 Volume 2012:5 Pages 715—718


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Makoto Saito,1 Masanobu Morioka,1 Ko Izumiyama,1 Akio Mori,1 Tatsuro Irie,1 Masanori Tanaka,1 Yoshihiro Matsuno2

1Department of Internal Medicine and Hematology, Aiiku Hospital, Sapporo, Japan; 2Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan

Abstract: We report a case of Epstein–Barr virus (EBV)-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement. A 34-year-old healthy Japanese male developed intussusception due to an ileal plasmacytoma. The lesion was positive for EBV-encoded small nuclear RNA in in situ hybridization, with the surrounding lymph nodes showing the expression of CD20. Tumor cells in the ileal and lymph node lesions contained high-grade malignant features compatible with plasmablastic lymphoma. Because his abdominal lymph nodes recurred 6 months after resection, he received six cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone), and had a complete remission. Although his case was complicated by acute promyelocytic leukemia, he has so far survived, recurrence-free, for more than 7.5 years after chemotherapy for extraosseous plasmacytoma.

Keywords: ileal extraosseous plasmacytoma, plasmablastic lymphoma, Epstein–Barr virus (EBV), lymph node involvement, CD20, R-CHOP

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