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Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Authors Xue B, Zhao J, Feng P, Xing J, Wu H, Li Y

Received 25 October 2018

Accepted for publication 10 December 2018

Published 11 January 2019 Volume 2019:12 Pages 549—559


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Sanjeev Srivastava

Video abstract presented by Busheng Xue.

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Busheng Xue,1 Jiansong Zhao,1 Penghui Feng,2 Jia Xing,3 Hongliang Wu,1 Yan Li1

1Department of Spine and Joint Surgery, Shengjing Hospital, China Medical University, Shenyang, People’s Republic of China; 2Department of Obstetrics and Gynecology-Reproductive Medical Center, Shengjing Hospital, China Medical University, Shenyang, People’s Republic of China; 3Department of Histology and Embryology, Basic Medicine College, China Medical University, Shenyang, People’s Republic of China

Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypomethylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study.

Keywords: UHRF1 protein complex, epigenetic modification, ICBP90

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