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Epidemiology and molecular diagnosis of acute conjunctivitis in patients attending Hamadan, west Iran ophthalmology clinics 2016–2017

Authors Johari Moghadam MM, Mohamad Yari M, Azizi Jalilian F, Amini R, Bazzazi N

Received 10 June 2019

Accepted for publication 29 August 2019

Published 15 October 2019 Volume 2019:11 Pages 105—111

DOI https://doi.org/10.2147/OPTO.S217722

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Mr Simon Berry


Mohamad Mehdi Johari Moghadam,1 Milad Mohamad Yari,2 Farid Azizi Jalilian,3 Razieh Amini,4 Nooshin Bazzazi5

1Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran; 2Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran; 3Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 4Department of Molecular Medicineand Genetics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 5Department of Ophthalmology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence: Farid Azizi Jalilian
Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan 6517838678, Iran
Tel +98 813 838 0462
Fax +98 813 838 0462
Email azizijfarid@yahoo.com

Razieh Amini
Department of Molecular Medicine and Genetics, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan 6517838678, Iran
Tel +98 813 838 0572
Fax +98 813 838 0208
Email ra.amini@umsha.ac.ir

Background: Viruses are considered the most common cause of infectious conjunctivitis. PCR has been approved as the best standard method to diagnose viral conjunctivitis. This study was conducted to investigate epidemiological patterns of conjunctivitis in Hamadan, west Iran. In addition, the frequency of the most important cause of infectious conjunctivitis diagnosed by PCR and its seasonal variations and association with certain socioeconomic and health factors were studied.
Methods: In this cross-sectional study, 125 patients with suspected viral conjunctivitis or keratoconjunctivitis in Hamadan, west Iran from July 2016 to June 2017 were examined for the presence of herpes simplex virus 1 (HSV1), HSV2, varicella-zoster virus (VZV), adenovirus. and Chlamydia trachomatis using multiplex real-time PCR.
Results: Adenoviruses were the most prevalent pathogens (94.4%). HSV1 was found in two (1.6%) patients. HSV2, VZV, and C. trachomatis were not seen in any patients. There was no difference in acquisition of conjunctivitis between men and women. A total of 55 (44%) patients attended the clinics in summer.
Conclusion: This study demonstrated that adenoviruses were a much more common viral cause of conjunctivitis in the studied region compared to findings in other regions. In addition, the acquisition rate of eye infection is expected to decrease dramatically in this region through control of adenoviruses. Demographic variables ie, age, sex, and income level, were not significantly associated with acquisition of viral infection.

Keywords: epidemiology, conjunctivitis, virus, polymerase chain reaction


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