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Epidemiology and clinical impact of major comorbidities in patients with COPD

Authors Smith MC, Wrobel JP

Received 9 March 2014

Accepted for publication 12 May 2014

Published 27 August 2014 Volume 2014:9(1) Pages 871—888

DOI https://doi.org/10.2147/COPD.S49621

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Miranda Caroline Smith,1 Jeremy P Wrobel2

1Respiratory Medicine, Royal Perth Hospital, Perth, WA, Australia; 2Advanced Lung Disease Unit, Royal Perth Hospital, Perth, WA, Australia

Abstract: Comorbidities are frequent in chronic obstructive pulmonary disease (COPD) and significantly impact on patients' quality of life, exacerbation frequency, and survival. There is increasing evidence that certain diseases occur in greater frequency amongst patients with COPD than in the general population, and that these comorbidities significantly impact on patient outcomes. Although the mechanisms are yet to be defined, many comorbidities likely result from the chronic inflammatory state that is present in COPD. Common problems in the clinical management of COPD include recognizing new comorbidities, determining the impact of comorbidities on patient symptoms, the concurrent treatment of COPD and comorbidities, and accurate prognostication. The majority of comorbidities in COPD should be treated according to usual practice, and specific COPD management is infrequently altered by the presence of comorbidities. Unfortunately, comorbidities are often under-recognized and under-treated. This review focuses on the epidemiology of ten major comorbidities in patients with COPD. Further, we emphasize the clinical impact upon prognosis and management considerations. This review will highlight the importance of comorbidity identification and management in the practice of caring for patients with COPD.

Keywords: cardiovascular disease, prevalence, mortality, chronic bronchitis, emphysema

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