Back to Journals » International Journal of Nanomedicine » Volume 9 » Issue 1

Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion

Authors Ding S, Zhang Z, Song J, Cheng X, Jiang J, Jia X

Received 17 January 2014

Accepted for publication 1 March 2014

Published 13 May 2014 Volume 2014:9(1) Pages 2327—2333


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Shu-min Ding,1–3 Zhen-hai Zhang,1,3 Jie Song,1,3 Xu-dong Cheng,1,3 Jun Jiang,1,3 Xiao-bin Jia1,3

1Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 2School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, People's Republic of China; 3Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, People's Republic of China

Abstract: In this study, a novel carbon nanopowder (CNP) drug carrier was developed to improve the oral bioavailability of apigenin (AP). Solid dispersions (SDs) of AP with CNP were prepared, and their in vitro drug release and in vivo performance were evaluated. The physicochemical properties of the formulations were examined by differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. Drug release profiles showed that AP dissolution from the CNP-AP system (weight ratio, 6:1) after 60 minutes improved by 275% compared with that of pure AP. Moreover, the pharmacokinetic analysis of SD formulations in rats showed that the AP area under the curve0–t value was 1.83 times higher for the CNP-AP system than for pure AP, indicating that its bioavailability was significantly improved. In addition, compared with pure AP, SDs had a significantly higher peak and shorter time to peak. Preliminary intestinal toxicity tests indicated that there was no significant difference in the tissues of the rats treated with the CNP-AP system, rats treated with the CNP alone, and controls. In conclusion, CNP-based SDs could be used for enhancing the bioavailability of poorly water-soluble drugs while also improving drug safety.

Keywords: apigenin, carbon nanopowder, solid dispersions, dissolution, oral bioavailability

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Readers of this article also read:

Self-assembled micelles of amphiphilic poly(L-phenylalanine)-b-poly(L-serine) polypeptides for tumor-targeted delivery

Zhao ZM, Wang Y, Han J, Wang KL, Yang D, Yang YH, Du Q, Song YJ, Yin XX

International Journal of Nanomedicine 2014, 9:5849-5862

Published Date: 12 December 2014

Proliferation and stemness preservation of human adipose-derived stem cells by surface-modified in situ TiO2 nanofibrous surfaces

Tan AW, Tay L, Chua KH, Ahmad R, Ali Akbar S, Pingguan-Murphy B

International Journal of Nanomedicine 2014, 9:5389-5401

Published Date: 21 November 2014

Synthesis, characterization, and antimicrobial activity of an ampicillin-conjugated magnetic nanoantibiotic for medical applications

Hussein-Al-Ali SH, El Zowalaty ME, Hussein MZ, Geilich BM, Webster TJ

International Journal of Nanomedicine 2014, 9:3801-3814

Published Date: 8 August 2014

Efficient gene delivery system mediated by cis-aconitate-modified chitosan-g-stearic acid micelles

Yao JJ, Du YZ, Yuan H, You J, Hu FQ

International Journal of Nanomedicine 2014, 9:2993-3003

Published Date: 18 June 2014

Nanosilver particles in medical applications: synthesis, performance, and toxicity

Ge L, Li Q, Wang M, Ouyang J, Li XJ, Xing MM

International Journal of Nanomedicine 2014, 9:2399-2407

Published Date: 16 May 2014

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Zhao S, Zhao J, Dong S, Huangfu X, Li B, Yang H, Zhao J, Cui W

International Journal of Nanomedicine 2014, 9:2373-2385

Published Date: 14 May 2014

Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells

Cui FB, Liu Q, Li RT, Shen J, Wu PY, Yu LX, Hu WJ, Wu FL, Jiang CP, Yue GF, Qian XP, Jiang XQ, Liu BR

International Journal of Nanomedicine 2014, 9:2345-2358

Published Date: 13 May 2014

Development of high drug-loading nanomicelles targeting steroids to the brain

Zheng S, Xie Y, Li Y, Li L, Tian N, Zhu W, Yan G, Wu C, Hu H

International Journal of Nanomedicine 2014, 9:55-66

Published Date: 18 December 2013

Characterization, activity, and computer modeling of a molecular inclusion complex containing rifaldazine

Tan Q, He D, Wu M, Yang L, Ren Y, Liu J, Zhang J

International Journal of Nanomedicine 2013, 8:477-484

Published Date: 1 February 2013