Back to Journals » Vascular Health and Risk Management » Volume 8

Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection

Authors Lind L, Hulthe J, Johansson A, Hedner E

Received 28 February 2011

Accepted for publication 15 May 2011

Published 24 July 2012 Volume 2012:8 Pages 447—453

DOI https://doi.org/10.2147/VHRM.S19161

Review by Single-blind

Peer reviewer comments 2

Lars Lind,1 Johannes Hulthe,2,3 Annika Johansson,3 Ewa Hedner3

1Department of Medicine, University Hospital, Uppsala, 2Sahlgrenska Hospital, Gothenburg, 3AstraZeneca Research and Development, Mölndal, Sweden

Background: Inflammation induced by either endotoxin or vaccination has previously been shown to impair endothelium-dependent vasodilation (EDV) in healthy young individuals. However, the vascular effects of these two mechanisms of inducing inflammation have not been compared in the same individuals.
Methods: Twelve young healthy males were studied at the same time of the day on three occasions in a random order; on one occasion 4 hours following an endotoxin injection (Escherichia coli endotoxin, 20 IU/kg), on another occasion 8 hours following vaccination against Salmonella typhi, and on a third occasion 4 hours following a saline control injection. EDV and endothelium-independent vasodilation (EIDV) were evaluated by local infusions of acetylcholine and sodium nitroprusside in the brachial artery, and forearm blood flow was measured with venous occlusion plethysmography. The augmentation index was determined by pulse wave analysis as an index of pulse wave reflection.
Results: Both endotoxin and vaccination impaired EDV to a similar degree compared with the saline control (P = 0.005 and P = 0.014, respectively). EIDV was not significantly affected by inflammation. Endotoxin, but not vaccination, increased body temperature and circulating levels of intracellular adhesion molecule-1 and interleukin-6. Augmentation index was not affected by the interventions.
Conclusion: Despite the fact that endotoxin induced a more pronounced degree of inflammation than vaccination, both inflammatory challenges impaired EDV to a similar degree, supporting the view that different inflammatory stimuli could induce harmful effects on the vasculature.

Keywords: endothelium, endotoxin, vaccination, vasodilation, inflammation

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Real-world effectiveness of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide in high-risk patients and other subgroups

Assaad-Khalil SH, Najem R, Sison J, Kitchlew AR, Cho BL, Ueng KC, DiTommaso S, Shete A

Vascular Health and Risk Management 2015, 11:71-78

Published Date: 21 January 2015

Effects of CPAP on "vascular" risk factors in patients with obstructive sleep apnea and arterial hypertension

Litvin AY, Sukmarova ZN, Elfimova EM, Aksenova AV, Galitsin PV, Rogoza AN, Chazova IE

Vascular Health and Risk Management 2013, 9:229-235

Published Date: 10 May 2013

Endoglin: a critical mediator of cardiovascular health

Kapur NK, Morine KJ, Letarte M

Vascular Health and Risk Management 2013, 9:195-206

Published Date: 6 May 2013

Diagnosis of carotid artery stenosis with oculopneumoplethysmography alone and in combination with MRA

Elias RM, Wald JT, Kallmes DF

Vascular Health and Risk Management 2012, 8:631-639

Published Date: 23 November 2012

Ezetimibe therapy: mechanism of action and clinical update

Phan BAP, Dayspring TD, Toth PP

Vascular Health and Risk Management 2012, 8:415-427

Published Date: 3 July 2012

Lift the quilt in case of atrial fibrillation and disc prolapse

Bastovansky A, Ziegler K, Stöllberger C, Finsterer J

Vascular Health and Risk Management 2012, 8:389-392

Published Date: 22 June 2012

Correlation of natriuretic peptides and inferior vena cava size in patients with congestive heart failure

Hebl V, Zakharova MY, Canoniero M, Duprez D, Garcia S

Vascular Health and Risk Management 2012, 8:213-218

Published Date: 10 April 2012