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Encephalitozoon cuniculi in pet rabbits: diagnosis and optimal management

Authors Latney L, Bradley C, Wyre N

Received 13 June 2013

Accepted for publication 13 August 2013

Published 6 November 2014 Volume 2014:5 Pages 169—180

DOI https://doi.org/10.2147/VMRR.S49842

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


La'Toya V Latney,1 Charles W Bradley,2 Nicole R Wyre1

1Departments of Clinical Studies, 2Departments of Pathobiology, Matthew J Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Abstract: Encephalitozoonosis is a significant microsporidial disease of captive pet rabbits (Oryctolagus cuniculus). This article overviews the life cycle, pathogenesis, and host immune response to the parasite. Clinical presentation, differential diagnoses, antemortem diagnostics, and postmortem diagnosis will be discussed. International seroprevalence data and histologic prevalence estimates in the US are presented. A review of current treatment and control recommendations are discussed based on extensive review of controlled studies, which have found fenbendazole to be effective for limiting spread of the disease.

Keywords: Encephalitozoon cuniculi, Oryctolagus cuniculi, microsporidia, encephalitozoonosis

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