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Emerging use of combination therapies for the management of type 2 diabetes – focus on saxagliptin and dapagliflozin

Authors Yu H, Woo VC

Received 21 February 2017

Accepted for publication 7 April 2017

Published 21 July 2017 Volume 2017:10 Pages 317—332

DOI https://doi.org/10.2147/DMSO.S117982

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Huan Yu, Vincent C Woo

Department of Medicine, Division of Endocrinology and Metabolism, Health Sciences Centre, University of Manitoba, Winnipeg, MB, Canada

Aims: The aim of this article is to review the safety and efficacy data of dapagliflozin, saxagliptin, and their combination in the management of patients with type 2 diabetes. Evidence for the use of the single-tablet combination formulation is also presented.
Methods: A nonsystematic literature review was performed using the Ovid, PubMed, and Google Scholar databases.
Results: The addition of dapagliflozin/saxagliptin to metformin can lower mean hemoglobin A1c by as much as 1.47% and lead to weight loss of 0.5–2.0 kg. The risk of genital infections with combination therapy is lower than observed with dapagliflozin alone, suggestive of a protective effect. Adverse event risk at 52-week follow-up was not increased beyond that seen with either monotherapy.
Conclusion: Dapagliflozin/saxagliptin combination is generally well tolerated and is an effective tool in helping patients with diabetes improve glycemic control.

Keywords: SGLT2 inhibitor, DPP4 inhibitor, single-tablet combination, diabetes mellitus

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