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Emerging role of cell polarity proteins in breast cancer progression and metastasis

Authors Chatterjee S, McCaffrey L

Received 17 October 2013

Accepted for publication 18 November 2013

Published 9 January 2014 Volume 2014:6 Pages 15—27


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Sudipa June Chatterjee, Luke McCaffrey

Rosalind and Morris Goodman Cancer Centre, Department of Oncology, McGill University, Montreal, QC, Canada

Abstract: Breast cancer is a heterogeneous group of diseases that frequently exhibits loss of growth control, and disrupted tissue organization and differentiation. Several recent studies indicate that apical–basal polarity provides a tumor-suppressive function, and that disrupting polarity proteins affects many stages of breast cancer progression from initiation through metastasis. In this review we highlight some of the recent advances in our understanding of the molecular mechanisms by which loss of apical–basal polarity deregulates apoptosis, proliferation, and promotes invasion and metastasis in breast cancer.

Keywords: apical, basal, oncogene, tumor suppressor, proliferation, apoptosis

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