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Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells

Authors Nakata S, Phillips E, Goidts V

Received 19 November 2013

Accepted for publication 27 December 2013

Published 24 March 2014 Volume 2014:6 Pages 171—180

DOI https://doi.org/10.2147/CMAR.S57846

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Susumu Nakata,1 Emma Phillips,2 Violaine Goidts2

1Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan; 2Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany

Abstract: The concept of cancer stem cells has gained considerable interest in the last few decades, partly because of their potential implication in therapy resistance. However, the lack of specific cellular surface markers for these cells has impeded their isolation, making the characterization of this cellular subpopulation technically challenging. Recent studies have indicated that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem cells. This review aims to give an overview of LGR4 and LGR5 as cancer stem cell markers and their function in development.

Keywords: glioblastoma, colorectal cancer, tissue stem cell marker

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