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Emerging clinical significance of claudin-7 in colorectal cancer: a review

Authors Wang K, Xu C, Li WJ, Ding L

Received 26 May 2018

Accepted for publication 10 July 2018

Published 20 September 2018 Volume 2018:10 Pages 3741—3752

DOI https://doi.org/10.2147/CMAR.S175383

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Kenan Onel


Kun Wang, Chang Xu, Wenjing Li, Lei Ding

Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China

Abstract: Tight junctions (TJs) play an important role in maintaining cell polarity and regulating cell permeability. In recent years, many studies have shown that TJ proteins, especially claudin-7, are closely related to inflammation and the development of various malignant tumors. Claudin-7 plays a significant role in maintaining the physiological functions and pathological conditions of the TJ barrier. The dysregulation of claudin-7 plays a tumor suppressor role or conversely has carcinogenic effects in different target tissues or cells, but the exact underlying mechanism is still unclear. In this review, we will summarize the expression pattern of claudin-7 in tumors, focusing on the expression and regulation of claudin-7 in colorectal cancer and discussing the correlation between claudin-7 and invasion, metastasis and epithelial–mesenchymal transition (EMT) in colorectal cancer. The construction of Cldn7−/− mice and conventional claudin-7 knockout mouse models has helped determine the mechanisms by which claudin-7 promotes tumorigenesis. Elucidation of the expression and subcellular localization of claudin-7 under pathological conditions will help develop claudin-7 as a useful biomarker for detecting and diagnosing cancer, and thus may help combat the occurrence, development, and invasion of cancers.

Keywords: tight junctions, claudin-7, tumors, colorectal cancer, invasion, metastasis

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