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Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage

Authors Gong X, Lu Z, Feng X, Yu C, Xue M, Yu L, Wang T, Cheng X, Lu J, Zhang M

Received 25 June 2020

Accepted for publication 31 August 2020

Published 21 September 2020 Volume 2020:16 Pages 2153—2159

DOI https://doi.org/10.2147/NDT.S269210

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Yuping Ning


Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Chuanqing Yu,1 Min Xue,1 Liang Yu,1 Tao Wang,1 Xiaosi Cheng,1 Jun Lu,4,5 Mei Zhang1

1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China; 2School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, People’s Republic of China; 3Department of Cardiothoracic Surgery, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China; 4Department of Medical Laboratory, School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, People’s Republic of China; 5Department of Clinical Laboratory, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Jun Lu
Department of Medical Laboratory, School of Medicine, Anhui University of Science and Technology, 168 Taifeng Road, Huainan 232001, Anhui Province, People’s Republic of China
Tel +86- 13855453149
Email cfdxlujun@126.com
Mei Zhang
Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, 203 Huaibin Road, Huainan 232007, Anhui Province, People’s Republic of China
Tel + 86- 13955466855
Email hnzhangmei2008@163.com

Purpose: Inflammation plays a critical role in the development of depression after intracerebral hemorrhage (ICH), while neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel comprehensive inflammatory indicator in recent years. The aim of this study was to examine the association between NLR and depression after ICH.
Patients and Methods: From January 2016 to December 2018, ICH patients were prospectively enrolled. NLR was measured at admission. Depression at 3 months after ICH was diagnosed according to the Hamilton Depression Scale (HAMD).
Results: Of the 372 enrolled patients, 107 (28.8%) were diagnosed with depression at 3 months after ICH. Patients with depression had a higher NLR (6.15 vs 3.55, P < 0.001). Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45– 3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis.
Conclusion: Elevated NLR is associated with depression at 3 months after ICH, suggesting that NLR may be a significant biomarker to predict depression after ICH.

Keywords: inflammation, neutrophil-to-lymphocyte ratio, depression, intracerebral hemorrhage

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