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Elevated HABP1 protein expression correlates with progression and poor survival in patients with gastric cancer

Authors Gao H, Yao Q, Lan X, Li S, Wu J, Zeng G, Xue Y

Received 10 June 2016

Accepted for publication 30 August 2016

Published 31 October 2016 Volume 2016:9 Pages 6711—6718


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Geoffrey Pietersz

Hongyu Gao,1 Qiang Yao,1 Xiuwen Lan,1 Sen Li,1 Junlong Wu,2 Guangchun Zeng,2 Yingwei Xue1

1Department of Gastroenterologic Surgery, 2Department of Pathology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, People’s Republic of China

Background: Hyaluronic acid-binding protein 1 (HABP1/gC1qR/p32) has been recently implicated in oncogenesis and cancer progression in various malignancies; however, its clinical role in gastric cancer (GC) is still unclear.
Patients and methods: First, HABP1 expression was determined by Western blot analysis and immunohistochemistry. Then, we evaluated the expression of HABP1 and its clinical significance in tumor tissues from 181 patients with GC.
Results: Expression of HABP1 protein in GC tissues was noticeably higher than that in adjacent nonneoplastic tissues (P=0.018). Increased HABP1 expression was significantly associated with tumor, node, and metastasis (TNM) stage (P=0.006), depth of invasion (P=0.001), lymph node metastasis (P=0.001), liver metastasis (P=0.024), and peritoneum metastasis (P=0.009). Patients with high expression of HABP1 had poor overall survival rate (P<0.001). In addition, histologic grade (P=0.017), TNM stage (P<0.001), Borrmann grouping (P<0.001), depth of invasion (P<0.001), lymph node metastasis (P<0.001), liver metastasis (P=0.010), and tumor size (P<0.001) were independent prognostic factors for overall survival. Multivariate Cox regression analysis revealed that HABP1 (P=0.004), histologic grade (P=0.047), TNM stage (P<0.001), Borrmann grouping (P<0.001), and liver metastasis (P=0.038) were independent factors for overall survival in patients with GC.
Conclusion: These findings demonstrated that HABP1 was an indicator for GC progression and poor survival, which highlighted its potential role as a therapeutic target for GCs.

Keywords: hyaluronic acid-binding protein 1, gastric cancer, overall survival rate, overexpression, prognosis

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