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Elevated expression of CXCL16 correlates with poor prognosis in patients with colorectal cancer

Authors Chen Z, Dai W, Yang L, Yang H, Ding L, He Y, Song X, Cui J

Received 6 December 2018

Accepted for publication 29 April 2019

Published 23 May 2019 Volume 2019:11 Pages 4691—4697

DOI https://doi.org/10.2147/CMAR.S197354

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr Antonella D'Anneo


Zhihui Chen,1,* Weigang Dai,1,* Liang Yang,1,* Hong Yang,2 Li Ding,3 Yulong He,1 Xinming Song,1 Ji Cui1

1Department of Gastrointestinal Surgery Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China; 2Operating Department, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 3Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China

*These authors contributed equally to this work

Aims:
To examine the expression of CXCL16 in colorectal cancer (CRC) tissue and to clarify the relationships between CXCL16 and clinicopathological features and survival in CRC.
Methods: A total of 142 consecutive CRC patients undergoing colorectal surgery at the Department of Gastrointestinal Center, First Affiliated Hospital, Sun Yat-sen University, between January 2010 and December 2010 were enrolled in this study. CXCL16 was measured by immunohistochemical staining in CRC tissue. Association between CXCL16 expression and clinicopathologic parameters was analyzed with a chi-square test. Survival curves were calculated by the Kaplan–Meier method, and the differences between CXCL16 high- and low-expression groups were analyzed using the log-rank test. Cox univariate and multivariate analyses were used to determine risk factors for overall survival (OS).
Results: CXCL16 expression was elevated in CRC. CXCL16-positive expression was significantly related to tumor size (P=0.043), tumor differentiation (P=0.046) and distant metastasis (P=0.038), and there was a trend toward lymph node metastasis (P=0.070). CXCL16 expression, together with differentiation, depth of invasion, lymph node metastasis, and distant metastasis, was a significant independent prognostic factor for OS of patients with CRC (HR 2.026, 95% CI 1.128–3.640, P=0.018).
Conclusion: CXCL16 expression was enhanced in CRC tissue and was negatively correlated with survival in CRC patients. Furthermore, CXCL16-positive expression was an independent prognostic factor for CRC patients, whilst the underlying mechanisms remain unclear; thus, further studies are needed.

Keywords: colorectal neoplasms, chemokine, CXCL16, prognosis

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