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Electrochemical behavior and assay of anti-Parkinson drug selegiline using cathodic adsorptive stripping square wave voltammetry in bulk form

Authors Sinha P, Shekhawat A, Sharma DK

Received 18 June 2015

Accepted for publication 10 August 2015

Published 23 October 2015 Volume 2015:5 Pages 21—28


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor A.M Kannan

Priyanka Sinha, Anjuman Shekhawat, Digish K Sharma

Electrochemical Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur, India

Abstract: The electrochemical reduction behavior of selegiline was investigated by cyclic voltammetry using glassy carbon electrode and validated by square wave cathodic adsorptive stripping voltammetry. Selegiline gave one well-defined reduction peak in the potential range −0.4 to −0.5 V versus Ag/AgCl electrode. The reduction process is irreversible and partial diffusion controlled. Various chemical and instrumental parameters affecting the electroanalytical response for the determination of selegiline were investigated and optimized. Under optimized conditions, the adsorptive stripping peak current is found to be linear over the concentration range of 3.0×10–7–2.5×10–5 M with a detection limit of 3.04×10–8 M and a lower limit of quantification of 1.01×10–7 M.

Keywords: selegiline, anti-Parkinson drug, glassy carbon electrode, square wave cathodic adsorptive stripping voltammetry, diffusion controlled

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