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Eight-week of low-intensive lifestyle modification does improve insulin resistance in adults with metabolic syndrome

Authors Lin YH, Huang H

Received 17 January 2019

Accepted for publication 5 March 2019

Published 2 May 2019 Volume 2019:12 Pages 613—621

DOI https://doi.org/10.2147/DMSO.S201526

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Yi-Hsin Lin,1 Hsuan Huang2

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taiwan Adventist Hospital, Taipei, Taiwan; 2Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan

Purpose: Improvements in insulin resistance have been observed by following lifestyle modification (LM) for adults with metabolic syndrome (MetS). However, these improvements are associated with relatively intensive and long-term duration LM, which is unlikely to be a part of routine practice for most people. This study examined the impact of a short-term (eight-week) low-intensive LM program on anthropomorphic parameters and insulin resistance in a community-based population.
Patients and methods: A total of 174 adults (67 with MetS) were enrolled in this retrospective observational study. The effects of the eight-week LM program on anthropomorphic parameters and glucose homeostasis were investigated.
Results: After the LM program, most anthropomorphic parameters in both groups were significantly improved (P<0.05). Glucose homeostasis significantly was improved (P<0.001) in the MetS group. A change in the homeostasis model assessment of insulin resistance (HOMA-IR) was positively associated with the baseline HOMA-IR level (R=0.75,  P<0.001).
Conclusion: A low-intensive eight-week LM program is an effective and efficient way to improve the anthropomorphic parameters and to reduce insulin resistance, especially for adults with MetS.

Keywords: lifestyle modification, insulin resistance, glucose homeostasis, metabolic syndrome


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