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Efinaconazole in the treatment of onychomycosis

Authors Lipner SR, Scher RK

Received 5 March 2015

Accepted for publication 13 April 2015

Published 1 June 2015 Volume 2015:8 Pages 163—172

DOI https://doi.org/10.2147/IDR.S69596

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Suresh Antony

Shari R Lipner, Richard K Scher

Department of Dermatology, Weill Cornell Medical College, New York, NY, USA

Abstract: Efinaconazole 10% topical solution is a new triazole recently approved for the treatment of onychomycosis. It inhibits fungal lanosterol 14α-demethylase in the ergosterol biosynthesis pathway, has potent antifungal activity against dermatophytes, as well as activity against Candida spp. and non-dermatophyte molds, and showed promising results in clinical trials. This review summarizes the mechanism of action, in vitro and in vivo data, clinical trials, safety, and quality-of-life data of efinaconazole as it applies to the treatment of onychomycosis.

Keywords: efinaconazole, Jublia, onychomycosis, fungal infection, nail infection
 

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