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Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
Authors Jin X, Zhang P, Luo L, Cheng H, Li Y, Du T, Zou B, Gou M
Received 11 January 2016
Accepted for publication 26 May 2016
Published 8 September 2016 Volume 2016:11 Pages 4535—4544
DOI https://doi.org/10.2147/IJN.S103994
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Yashdeep Phanse
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Xun Jin,1 Peilan Zhang,1 Li Luo,1 Hao Cheng,1 Yunzu Li,1 Ting Du,1 Bingwen Zou,2 Maling Gou1
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China; 2Department of Thoracic Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China
Abstract: Nanoparticles have promising applications in drug delivery for cancer therapy. Herein, we prepared cationic 1,2-dioleoyl-3-trimethylammonium propane/methoxypoly (ethyleneglycol) (DPP) nanoparticles to deliver doxorubicin (Dox) for intravesical therapy of bladder cancer. The DPP micelles have a mean dynamic diameter of 18.65 nm and a mean zeta potential of +19.6 mV. The DPP micelles could prolong the residence of Dox in the bladder, enhance the penetration of Dox into the bladder wall, and improve cellular uptake of Dox. The encapsulation by DPP micelles significantly improved the anticancer effect of Dox against orthotopic bladder cancer in vivo. This work described a Dox-loaded DPP nanoparticle with potential applications in intravesical therapy of bladder cancer.
Keywords: bladder cancer, drug delivery, nanoparticles, intravesical therapy
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