Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo

Authors Zhang H, Zheng D, Ding J, Xu H, Li X, Sun W

Received 6 November 2014

Accepted for publication 28 December 2014

Published 11 March 2015 Volume 2015:10(1) Pages 1909—1920

DOI https://doi.org/10.2147/IJN.S77125

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Lei Yang

Hao Zhang,1,* Donghui Zheng,2,* Jing Ding,3 Huae Xu,4 Xiaolin Li,1 Weihao Sun1

1Department of Geriatric Gastroenterology, First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Nephrology, Huai’an Hospital Affiliated with Xuzhou Medical College and Huai’an Second Hospital, Huai’an, People’s Republic of China; 3Department of Respiratory Medicine, Affiliated Nanjing Children Hospital with Nanjing Medical University, 4Department of Pharmacy, First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China

*These authors contributed equally to this article


Abstract: Previous reports have shown that ursolic acid (UA), a pentacyclic triterpenoid derived from Catharanthus trichophyllus roots, could inhibit the growth of a series of cancer cells. However, the potential for clinical application of UA is greatly hampered by its poor solubility, whereas the hydrophobicity of UA renders it a promising model drug for nanosized delivery systems. In the current study, we loaded UA into amphiphilic poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles and performed physiochemical characterization as well as analysis of the releasing capacity. In vitro experiments indicated that UA-NPs inhibited the growth of liver cancer cells and induced cellular apoptosis more efficiently than did free UA. Moreover, UA-NPs significantly delayed tumor growth and localized to the tumor site when compared with the equivalent dose of UA. In addition, both western blotting and immunohistochemistry suggested that the possible mechanism of the superior efficiency of UA-NPs is mediation by the regulation of apoptosis-related proteins. Therefore, UA-NPs show potential as a promising nanosized drug system for liver cancer therapy.

Keywords: apoptosis, liver cancer, drug delivery, antitumor

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Synergistic anti-glioma effect of a coloaded nano-drug delivery system

Xu H, Jia F, Singh PK, Ruan S, Zhang H, Li X

International Journal of Nanomedicine 2017, 12:29-40

Published Date: 16 December 2016

Readers of this article also read:

Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo

Zheng K, Li R, Zhou X, Hu P, Zhang Y, Huang Y, Chen Z, Huang M

International Journal of Nanomedicine 2015, 10:5327-5342

Published Date: 24 August 2015

Docetaxel-loaded solid lipid nanoparticles as a basis for a targeted and dose-sparing personalized breast cancer treatment strategy

Danilova NV, Kalzhanov ZR, Nefedova NA, Mal’kov PG, Kosmas IP, Eliseeva MY, Mynbaev OA

International Journal of Nanomedicine 2015, 10:2417-2421

Published Date: 25 March 2015

Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery

Zhang L, Zhu D, Dong X, Sun H, Song C, Wang C, Kong D

International Journal of Nanomedicine 2015, 10:2101-2114

Published Date: 16 March 2015

In vitro percutaneous penetration and characterization of silver from silver-containing textiles

Bianco C, Kezic S, Crosera M, Svetličić V , Šegota S, Maina G, Romano C, Larese F, Adami G

International Journal of Nanomedicine 2015, 10:1899-1908

Published Date: 10 March 2015

Accessing to the minor proteome of red blood cells through the influence of the nanoparticle surface properties on the corona composition

Zaccaria A, Roux-Dalvai F, Bouamrani A, Mombrun A, Mossuz P, Monsarrat B, Berger F

International Journal of Nanomedicine 2015, 10:1869-1883

Published Date: 9 March 2015

Quantum dot-based multiplexed imaging in malignant ascites: a new model for malignant ascites classification

Zeng WJ, Peng CW, Yuan JP, Cui R, Li Y

International Journal of Nanomedicine 2015, 10:1759-1768

Published Date: 5 March 2015

Development of an oral push–pull osmotic pump of fenofibrate-loaded mesoporous silica nanoparticles

Zhao Z, Wu C, Zhao Y, Hao Y, Liu Y, Zhao W

International Journal of Nanomedicine 2015, 10:1691-1701

Published Date: 3 March 2015

An efficient method for in vitro gene delivery via regulation of cellular endocytosis pathway

Luo J, Li C, Chen J, Wang G, Gao R, Gu Z

International Journal of Nanomedicine 2015, 10:1667-1678

Published Date: 2 March 2015

Enhanced photodynamic leishmanicidal activity of hydrophobic zinc phthalocyanine within archaeolipids containing liposomes

Perez AP, Casasco A, Schilrreff P, Defain Tesoriero MV, Duempelmann L, Altube MJ, Higa L, Morilla MJ, Petray P, Romero EL

International Journal of Nanomedicine 2014, 9:3335-3345

Published Date: 10 July 2014