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Efficacy of Ustekinumab Against Spondyloarthritis Associated with Crohn’s Disease: A Case Report and Review of the Literature

Authors Matsumoto S, Matsumoto K, Takaya H, Otake H, Mashima H

Received 18 May 2020

Accepted for publication 14 July 2020

Published 29 July 2020 Volume 2020:12 Pages 133—137

DOI https://doi.org/10.2147/OARRR.S263259

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Chuan-Ju Liu


Satohiro Matsumoto, Keita Matsumoto, Hiromu Takaya, Haruka Otake, Hirosato Mashima

Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan

Correspondence: Satohiro Matsumoto Email s.w.himananon@ac.auone-net.jp

Abstract: Spondyloarthritis (SpA) is a known extraintestinal complication in inflammatory bowel disease (IBD). However, since the prevalence of SpA is lower in Japan than in Europe, some patients may be inaccurately diagnosed and treated. Although non-steroidal anti-inflammatory drugs (NSAIDs) remain the mainstay treatment for IBD-related SpA, anti-tumor necrosis factor-α antibody and ustekinumab have demonstrated efficacy in patients with SpA refractory to NSAIDs. We report here a case of Crohn’s disease with SpA, as an extraintestinal manifestation, in which ustekinumab proved extremely effective, not only for alleviating the arthritis but also against skin manifestations and scleritis. Only a few studies have documented the therapeutic effects of ustekinumab against SpA associated with IBD; therefore, its efficacy remains unclear.

Keywords: ustekinumab, spondyloarthritis, Crohn’s disease

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