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Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation

Authors Kozobolis V, Konstantinidis A, Sideroudi H, Teus M

Received 2 May 2018

Accepted for publication 12 September 2018

Published 23 November 2018 Volume 2018:12 Pages 2393—2398


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Vassilios Kozobolis,1,2 Aristeidis Konstantinidis,1,2 Haris Sideroudi,2 Miguel Teus3

1Department of Ophthalmology, Democritus University of Thrace, Alexandroupolis, Greece; 2Eye Institute of Thrace (EIT), Democritus University of Thrace, Alexandroupolis, Greece; 3University of Alcala, Madrid, Spain

Purpose: To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0.1% gel formulation (Trav + Geltim).
Materials and methods: Thirty-three patients (62 eyes) were enrolled and divided into two groups. Patients in group 1 (31 eyes) received the TTFC and patients in group 2 (31 eyes) received the concomitant treatment with Trav + Geltim. Patients on previous antiglaucoma treatment discontinued their drops for 2–4 weeks before starting their new treatment (TTFC or Trav + Geltim). The drops were instilled in the evening in group 1 and in group 2, the prostaglandin was installed in the evening, and timolol in the morning. IOP was measured at 1 and 3 months after the initiation of treatment at four time points during the day (09:00, 12:00, 15:00, and 18:00).
Results: Both groups showed significant IOP reduction from baseline at all time points at 1 and 3 months. When the two groups were compared, group 2 showed slightly better hypotensive effect that reached statistical significance only at the 18:00 time point at both 1 and 3 months.
Both the TTFC and the concomitant use of the travoprost/timolol gel showed similar hypotensive effect with the latter being slightly more potent in reducing the IOP.

Keywords: prostaglandin, timolol gel, glaucoma, fixed combination

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