Back to Journals » Clinical Ophthalmology » Volume 7

Efficacy of repeated 5-fluorouracil needling for failing and failed filtering surgeries based on simple gonioscopic examination

Authors Rashad M

Received 9 June 2012

Accepted for publication 3 September 2012

Published 28 December 2012 Volume 2013:7 Pages 15—22


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Mohammad A Rashad

Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Purpose: To evaluate the success rate of a modified bleb needling technique in eyes with previous glaucoma surgery that had elevated intraocular pressure.
Methods: A retrospective study of 24 eyes of 24 patients that underwent repeated bleb needling performed for failing and failed blebs on slit lamp with 5-fluorouracil (5-FU) injections on demand. This was performed after gonioscopic examination to define levels of filtration block.
Results: There was significant reduction of mean IOP from 36.91 mmHg to 14.73 mmHg at the final follow-up (P < 0.001). The overall success rate was 92%.
Conclusion: Repeated needling with adjunctive 5-FU proved a highly effective, safe alternative to revive filtration surgery rather than another medication or surgery.

Keywords: bleb, failure, 5-FU, needling, gonioscopy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Readers of this article also read:

Acquired hemophilia A: emerging treatment options

Janbain M, Leissinger CA, Kruse-Jarres R

Journal of Blood Medicine 2015, 6:143-150

Published Date: 8 May 2015

A multidimensional risk factor model for suicide attempts in later life

Chan SMS, Chiu FKH, Lam CWL, Wong SMC, Conwell Y

Neuropsychiatric Disease and Treatment 2014, 10:1807-1817

Published Date: 18 September 2014

Dendrimers functionalized with membrane-interacting peptides for viral inhibition

Tarallo R, Carberry TP, Falanga A, Vitiello M, Galdiero S, Galdiero M, Weck M

International Journal of Nanomedicine 2013, 8:521-534

Published Date: 5 February 2013

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010